跳轉至內容
Merck
全部照片(1)

Key Documents

View All Documentation

UC280

Sigma-Aldrich

酮康唑

同義詞:

(±)-顺-1-乙酰基-4-(4-[(2-[2,4-二氯苯基]-2-[1H-咪唑-1-基甲基]-1,3-二氧戊环-4-基)-甲氧基]苯基)哌嗪

登入查看組織和合約定價
全部照片(1)

About This Item

經驗公式（希爾表示法）:
C26H28Cl2N4O4
CAS號碼:
65277-42-1
分子量：:
531.43
EC號碼:
265-667-4
MDL號碼:
MFCD00058579
分類程式碼代碼:
12161501
PubChem物質ID:
24724652
NACRES:
NA.77

化驗

≥99% (HPLC)

形狀

solid

顏色

white to light yellow

溶解度

DMSO: soluble

抗生素活性譜

fungi
yeast

作用方式

enzyme | inhibits

起源

Johnson & Johnson

儲存溫度

2-8°C

SMILES 字串

CC(=O)N1CCN(CC1)c2ccc(OC[C@H]3CO[C@@](Cn4ccnc4)(O3)c5ccc(Cl)cc5Cl)cc2

InChI

1S/C26H28Cl2N4O4/c1-19(33)31-10-12-32(13-11-31)21-3-5-22(6-4-21)34-15-23-16-35-26(36-23,17-30-9-8-29-18-30)24-7-2-20(27)14-25(24)28/h2-9,14,18,23H,10-13,15-17H2,1H3/t23-,26-/m0/s1

InChI 密鑰

XMAYWYJOQHXEEK-OZXSUGGESA-N

基因資訊

human ... ABCB1(5243) , CYP11B1(1584) , CYP11B2(1585) , CYP17A1(1586) , CYP19A1(1588) , CYP1A2(1544) , CYP24A1(1591) , CYP26A1(1592) , CYP3A4(1576) , CYP51A1(1595) , KCNH1(3756)
mouse ... Abcb1a(18671) , Abcb1b(18669)
rat ... Alox5(25290) , Cyp17a1(25146) , Cyp51(25427) , Cyp7a1(25428)

尋找類似的產品？ 前往 產品比較指南

應用

酮康唑作为细胞色素 P450（CYP）抑制剂用于研究其在大鼠胚胎睾丸中的作用。酮康唑也用于筛选杀灭非复制型结核分枝杆菌的抗菌药物 。此外，研究曾将酮康唑用于抗真菌药物敏感性试验 ，也用作标准抗真菌药物 。
CYP3A4抑制剂

生化／生理作用

酮康唑是一种咪唑衍生物。它在对真菌细胞壁中的羊毛固醇转化为麦角固醇的抑制中起着重要作用。酮康唑对皮肤癣菌病、浅部念珠菌病和副球孢子菌病均有疗效。
抗真菌剂

特點和優勢

该化合物由 强生公司 开发。如需浏览其他制药公司开发的化合物和批准的药物/候选药物列表，请点击此处。
这种化合物是 ADME 毒性研究的特色产品。点击此处查看更多特色 ADME 毒性产品。登录sigma.com/discover-bsm可了解更多关于其他研究领域中关于生物活性小分子的消息。

包裝

无底玻璃瓶。内含物装在插入式熔锥内。

準備報告

酮康唑可溶于 DMSO 。

訊號詞

Danger

危險分類

Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Repr. 1B - STOT RE 2

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

分析證明 (COA)

輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。

已經擁有該產品？

您可以在文件庫中找到最近購買的產品相關文件。

存取文件庫

Po-Ren Hsueh et al.
Antimicrobial agents and chemotherapy, 49(2), 512-517 (2005-01-28)
The susceptibilities of nonduplicate isolates to six antifungal agents were determined for 391 blood isolates of seven Candida species, 70 clinical isolates (from blood or cerebrospinal fluid) of Cryptococcus neoformans, and 96 clinical isolates of four Aspergillus species, which were
Gökalp Işcan et al.
Journal of agricultural and food chemistry, 50(14), 3943-3946 (2002-06-27)
Essential oils of peppermint Mentha piperita L. (Lamiaceae), which are used in flavors, fragrances, and pharmaceuticals, were investigated for their antimicrobial properties against 21 human and plant pathogenic microorganisms. The bioactivity of the oils menthol and menthone was compared using
Jana Koubova et al.
Proceedings of the National Academy of Sciences of the United States of America, 103(8), 2474-2479 (2006-02-08)
In mammals, meiosis is initiated at different time points in males and females, but the mechanism underlying this difference is unknown. Female germ cells begin meiosis during embryogenesis. In males, embryonic germ cells undergo G0/G1 mitotic cell cycle arrest, and
Ketoconazole.
Hay, R.
British Medical Journal (Clinical Research ed.), 285(6342), 584-584 (1982)
Bhaskar Das et al.
Frontiers in pharmacology, 13, 990926-990926 (2023-01-24)
Mollugo oppositifolia Linn. is traditionally used in neurological complications. The study aimed to investigate in-vitro neuroprotective effect of the plant extracts through testing against acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and β-secretase linked to Alzheimer's disease (AD). To understand the safety aspects
查看所有相關論文

我們的科學家團隊在所有研究領域都有豐富的經驗，包括生命科學、材料科學、化學合成、色譜、分析等.

聯絡技術服務