SML1851

RI(dl)-2

≥98% (HPLC)

• 同義詞: N-Ethyl-4-(pyrrolo[1,2-a]quinoxalin-4-yl)aniline
• 經驗公式（希爾表示法）: C₁₉H₁₇N₃ · xC₂HF₃O₂
• CAS號碼: 1902146-75-1
• 分子量：: 287.36 (free base basis)
• 分類程式碼代碼: 12352200
• NACRES: NA.77

屬性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: powder
• 顏色: , light orange to dark red
• 溶解度: DMSO: 20 mg/mL, clear
• 儲存溫度: 2-8°C
• SMILES 字串: CCNC1=CC=C(C2=NC3=C(N4C2=CC=C4)C=CC=C3)C=C1.FC(F)(C(O)=O)F

描述

生化／生理作用

RI(dl)-2 is a cell-permeable pyrroloquinoxaline derivative that selectively inhibits Rad51-mediated D-loop formation (IC₅₀ = 11.1 μM) without affecting its ssDNA-binding activity (IC₅₀ >100 μM). RI(dl)-2 is shown to inhibit DSBs-induced cellular homologous recombination (HR) activity (IC₅₀ = 3.0 μM by HEK293-based DR-GFP reporter assay) by stabilizing nucleoprotein filaments in a nonfunctional state without affecting DNA damage-induced RAD51 nuclear loci formation or stimulating single-strand annealing (SSA) activity.

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable