推薦產品
品質等級
化驗
≥98% (HPLC)
形狀
powder
顏色
white to tan
溶解度
DMSO: 12 mg/mL, clear
儲存溫度
2-8°C
SMILES 字串
COC(=O)C1(C)N(CCc2c1[nH]c3ccccc23)C(=O)CCl
InChI
1S/C16H17ClN2O3/c1-16(15(21)22-2)14-11(7-8-19(16)13(20)9-17)10-5-3-4-6-12(10)18-14/h3-6,18H,7-9H2,1-2H3
InChI 密鑰
BCSIRYFYAKLJDK-UHFFFAOYSA-N
應用
PDI 抑制剂 16F16 可用于蛋白质二硫键异构酶介导的细胞信号传导研究。
PDI抑制剂16F16已被用于抑制PDI（蛋白质二硫键异构酶）的功能，以检测人胚肾细胞中PDI的功能保守性（functional conservation）。
生化／生理作用
16F16 是一种蛋白质二硫键异构酶 (PDI) 抑制剂，首次在屏幕亨廷顿蛋白诱导细胞凋亡的化合物筛选中发现。16F16 不仅能抑制错误折叠的蛋白突变体亨廷顿基因诱导的细胞凋亡，还能保护大鼠神经元免受 Aβ 肽引发的细胞死亡。这种抑制剂的作用有助于确定一个新的机制，在这个机制中，细胞死亡途径通过 PDI 上调被蛋白质错误折叠调节。
蛋白质二硫键异构酶 (PDI) 抑制剂；抑制错误折叠蛋白诱导的细胞凋亡
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
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