推薦產品
品質等級
化驗
≥98% (HPLC)
形狀
powder
顏色
white to beige
溶解度
DMSO: 5 mg/mL, clear (warmed)
儲存溫度
−20°C
InChI
1S/C11H8O4/c1-6-4-10(14)15-11-7(6)2-3-9(13)8(11)5-12/h2-5,13H,1H3
InChI 密鑰
RTHHSXOVIJWFQP-UHFFFAOYSA-N
生化／生理作用
4μ8C 是内质网跨膜蛋白 IRE1 的强效抑制剂，介导未折叠蛋白反应。4μ8C 抑制调节的 IRE1 依赖性降解 (RIDD) 和 XBP1 mRNA 对内质网 (ER) 应激的非常规剪接，但对 IRE1 的激酶活性没有影响。
4μ8C 是水杨醛衍生物，其抑制作用靶向 RNase（核糖核酸酶）结构域中的 K907 赖氨酸残基，影响 IRE1αRNase 活性。体外 分析证明 4μ8C 能够在高糖水平抑制胰岛素的释放。
特點和優勢
这种化合物是基因调控研究的特色产品。点击此处发现更多特色基因调控产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
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Endoplasmic reticulum (ER) stress can be induced by various stimuli and triggers the unfolded protein response to activate intracellular signaling pathways that are mediated by 3 ER-resident sensors: inositol requiring protein-1α (IRE1α), PKR-like ER kinase (PERK), and activating transcription factor-6
我們的科學家團隊在所有研究領域都有豐富的經驗，包括生命科學、材料科學、化學合成、色譜、分析等.
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