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T6154

Sigma-Aldrich

曲唑酮 盐酸盐

≥99% (HPLC), powder

同義詞:

2- [3- [4-（3-氯苯基）-1-哌嗪基] 丙基]-1,2,4-三唑 [4,3-a] 吡啶-3 (2H)-酮 盐酸盐

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About This Item

經驗公式（希爾表示法）:
C19H22ClN5O · HCl
CAS號碼:
25332-39-2
分子量：:
408.32
EC號碼:
246-855-5
MDL號碼:
MFCD00079603
分類程式碼代碼:
12352200
PubChem物質ID:
24278136
NACRES:
NA.77

品質等級

200

化驗

≥99% (HPLC)

形狀

powder

溶解度

45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: soluble 23.3 mg/mL
methanol: soluble 25 mg/mL, clear, colorless
0.1 M HCl: soluble 7.4 mg/mL
DMSO: soluble
H2O: soluble, hazy, colorless

起源

Bristol-Myers Squibb

SMILES 字串

Cl[H].Clc1cccc(c1)N2CCN(CCCN3N=C4C=CC=CN4C3=O)CC2

InChI

1S/C19H22ClN5O.ClH/c20-16-5-3-6-17(15-16)23-13-11-22(12-14-23)8-4-10-25-19(26)24-9-2-1-7-18(24)21-25;/h1-3,5-7,9,15H,4,8,10-14H2;1H

InChI 密鑰

OHHDIOKRWWOXMT-UHFFFAOYSA-N

基因資訊

human ... HTR1A(3350) , HTR1B(3351) , HTR1D(3352) , HTR1E(3354) , HTR1F(3355) , HTR2A(3356) , HTR2C(3358) , SLC6A4(6532)

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生化／生理作用

增强 5-羟色胺摄取阻断剂活性、并具有完全5-HT 2C 5 羟色胺受体激动剂活性的抗抑郁药。它代谢为 5-HT 1 5-羟色胺受体激动剂 1-（3-氯苯基）哌嗪。

特點和優勢

该化合物收录于 受体分类和信号转导手册的《生物胺转运体 》页面。想要浏览手册的其他页面， 请单击此处。
该化合物由Bristol-Myers Squibb开发。要浏览其他药物开发化合物和批准的药物/候选药物列表，单击此处。

準備報告

盐酸曲唑酮溶于 25 mg/mL 甲醇中，得到澄清、无色溶液。在 50 mg/mL 的水中溶解，加热得到浑浊的无色溶液。此外，产品可溶于 DMSO 或 0.1 NHCl (7.4 mg/mL)。在45% (w/v) 2-羟丙基-β-环糊精水溶液中的溶解度为 23.3 mg/mL。然而，它几乎不溶于其他常见有机溶剂。对于 HPLC 检测，本品可以 0.25 mg/mL 溶于 50:50 水：甲醇 (v/v) 中，因为其获得的溶出度和峰形结果优于本品 1 mg/mL 水溶液。

象形圖

Health hazardExclamation mark
GHS08,GHS07

訊號詞

Warning

危險聲明

H302,H351

危險分類

Acute Tox. 4 Oral - Carc. 2

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

個人防護裝備

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

從最近期的版本中選擇一個：

分析證明 (COA)

Lot/Batch Number
MKCP5549
MKCN6829
MKCM5195
MKCK6828
MKCG3775

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存取文件庫

M Marcoli et al.
The Journal of pharmacology and experimental therapeutics, 285(3), 983-986 (1998-06-17)
The effects of trazodone on the cyclic GMP elevation elicited by N-methyl-D-aspartate in rat cerebellar slices were analyzed. Trazodone inhibited in a concentration-dependent manner (EC50 = 0.82 nM) the cyclic GMP response evoked by 0.1 microM N-methyl-D-aspartate. The inhibition was
J P Feighner
The Journal of clinical psychiatry, 60 Suppl 4, 4-11 (1999-03-23)
The psychopharmacology of depression is a field that has evolved rapidly in just under 5 decades. Early antidepressant medications--tricyclic antidepressants (TCAs) and monoamine oxidase inhibitors (MAOIs)--were discovered through astute clinical observations. These first-generation medications were effective because they enhanced serotonergic
M Pazzagli et al.
European journal of pharmacology, 383(3), 249-257 (1999-12-14)
The effects of the antidepressant drug, trazodone, on the extracellular 5-hydroxytryptamine (5-HT) levels in the frontal cortex of freely moving rats was investigated using microdialysis coupled to a high performance liquid chromatography (HPLC) detection method. Systemic administration of 1.25 and
Arnaud Devresse et al.
Acta gastro-enterologica Belgica, 75(2), 263-265 (2012-08-09)
We present the case of a 26-year-old man with schizoid personality disorder who suffered from a very focal and transparietal necrosis of the sigmoid after an overdose of atypical neuroleptics. This is a singular, rather unknown and potentially lethal side
Deena Ababneh et al.
Birth defects research. Part B, Developmental and reproductive toxicology, 95(2), 184-193 (2012-04-25)
This study investigated the effects of a range of antidepressant drugs on the heart of gestation day 13 rat embryos in vitro. The general hypothesis was that the drugs would adversely affect the function of the embryonic heart since they
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