跳轉至內容
Merck
全部照片(3)

Key Documents

更多文件

F132

Sigma-Aldrich

氟西汀 盐酸盐

≥98% (TLC), solid, selective serotonin reuptake inhibitor 

同義詞:

氟西汀 HCl, (±)-N-甲基-γ-[4-(三氟甲基)苯氧基]苯丙胺 盐酸盐, LY-110,140 盐酸盐, Prozac®

登入查看組織和合約定價
全部照片(3)

About This Item

經驗公式（希爾表示法）:
C17H18F3NO · HCl
CAS號碼:
56296-78-7
分子量：:
345.79
EC號碼:
260-101-2
MDL號碼:
MFCD00214288
分類程式碼代碼:
12352200
PubChem物質ID:
24278096
NACRES:
NA.77

product name

氟西汀 盐酸盐, solid

形狀

solid

顏色

white

溶解度

H2O: 4 mg/mL
DMSO: >5 mg/mL

起源

Eli Lilly

SMILES 字串

CNCCC(C1=CC=CC=C1)OC2=CC=C(C(F)(F)F)C=C2.[H]Cl

InChI

1S/C17H18F3NO.ClH/c1-21-12-11-16(13-5-3-2-4-6-13)22-15-9-7-14(8-10-15)17(18,19)20;/h2-10,16,21H,11-12H2,1H3;1H

InChI 密鑰

GIYXAJPCNFJEHY-UHFFFAOYSA-N

基因資訊

human ... HTR1A(3350) , HTR1B(3351) , HTR1D(3352) , HTR1E(3354) , HTR1F(3355) , HTR2A(3356) , HTR2B(3357) , HTR2C(3358) , HTR3A(3359) , HTR3B(9177) , HTR3C(170572) , HTR3D(200909) , HTR3E(285242) , HTR4(3360) , HTR5A(3361) , HTR5B(645694) , HTR6(3362) , HTR7(3363) , SLC6A4(6532)

尋找類似的產品？ 前往 產品比較指南

一般說明

盐酸氟西汀是一种精神类药物，是最早的抗抑郁药物之一，是选择性血清素再摄取抑制剂。它是百忧解有效成分之一。®

應用

盐酸氟西汀可以用于研究它对于小鼠放射药物 123I-标记2-（（2-（（二甲基氨基）甲基）苯基）硫基）-5-碘苯基胺([123I]ADAM)和SERT（血清素载体）结合的作用。它还可用于光照不足动物的长期治疗。

生化／生理作用

盐酸氟西汀是选择性血清素再摄取抑制剂，可用作抗抑郁药物。该药物作用于突触前末梢，它能够避免血清素再摄取，导致突触细胞外液体中血清素积累。
选择性羟色胺再摄取抑制剂；抗抑郁剂。

特點和優勢

该化合物是ADME Tox和胞凋亡研究的特色产品。发现更多的ADME Tox和细胞凋亡特色产品。想要了解有关生物活性小分子在其他研究领域应用的更多信息，请访问 sigma.com/discover-bsm。
该化合物是由 Eli Lilly研发。想要浏览其他由制药公司开发的化合物以及已批准物/候选药物清单， 请单击此处。
该化合物被记录在受体分类和信号传导手册生物胺转运蛋白和氯化物通道网页上。想要浏览手册的其他页面， 请单击此处。

法律資訊

经 Eli Lilly and Company 授权销售。
Prozac is a registered trademark of Eli Lilly and Co.

訊號詞

Danger

危險分類

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - STOT RE 2 - STOT SE 3

標靶器官

Central nervous system

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

分析證明 (COA)

輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。

已經擁有該產品？

您可以在文件庫中找到最近購買的產品相關文件。

存取文件庫

Maria T Accioly et al.
Cancer research, 68(6), 1732-1740 (2008-03-15)
Lipid bodies (lipid droplets) are emerging as dynamic organelles involved in lipid metabolism and inflammation. Increased lipid body numbers have been described in tumor cells; however, its functional significance in cancer has never been addressed. Here, we showed increased number
Darlene C Deecher et al.
The Journal of pharmacology and experimental therapeutics, 318(2), 657-665 (2006-05-06)
The purpose of this study was to characterize a new chemical entity, desvenlafaxine succinate (DVS). DVS is a novel salt form of the isolated major active metabolite of venlafaxine. Competitive radioligand binding assays were performed using cells expressing either the
T Frisan et al.
Blood, 86(4), 1493-1501 (1995-08-15)
Epstein-Barr virus (EBV)-positive Hodgkin's and Reed-Sternberg (HRS) cells express the virus-encoded latent membrane proteins LMP1 and LMP2 that could serve as rejection targets in Hodgkin's disease (HD). To examine whether EBV-triggered reactivities can be detected in the tumor, we have
Chaoran Ren et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 38(7), 1163-1175 (2013-02-02)
Light is a powerful modulator of higher-order cognitive processes such as mood but it remains unclear which neural circuits mediate the impact of light on affective behavior. We found that light deprivation produces a depressive-like behavioral state that is reversed
Aaron S Andalman et al.
Cell, 177(4), 970-985 (2019-04-30)
Prolonged behavioral challenges can cause animals to switch from active to passive coping strategies to manage effort-expenditure during stress; such normally adaptive behavioral state transitions can become maladaptive in psychiatric disorders such as depression. The underlying neuronal dynamics and brainwide
查看所有相關論文

我們的科學家團隊在所有研究領域都有豐富的經驗，包括生命科學、材料科學、化學合成、色譜、分析等.

聯絡技術服務