C2755

Cortisone

≥95%

• 同義詞: 17α,21-Dihydroxy-4-pregnene-3,11,20-trione, 17α-Hydroxy-11-dehydrocorticosterone, 4-Pregnene-17α,21-diol-3,11,20-trione, Kendall’s Compound E, Reichstein’s Substance Fa
• 經驗公式（希爾表示法）: C₂₁H₂₈O₅
• CAS號碼: 53-06-5
• 分子量：: 360.44
• Beilstein: 1356062
• EC號碼: 200-162-4
• MDL號碼: MFCD00003610
• 分類程式碼代碼: 51111800
• PubChem物質ID: 24278304
• NACRES: NA.77

屬性

• 生物源: synthetic
• 品質等級: 200
• 無菌: non-sterile
• 化驗: ≥95%
• 形狀: powder
• 技術: inhibition assay: suitable
• mp: 223-228 °C (dec.) (lit.)
• 溶解度: chloroform: methanol (1:1): 50 mg/mL, clear to very slightly hazy, colorless to faintly yellow
• 運輸包裝: ambient
• 儲存溫度: room temp
• SMILES 字串: C[C@]12CCC(=O)C=C1CC[C@H]3[C@@H]4CC[C@](O)(C(=O)CO)[C@@]4(C)CC(=O)[C@H]23
• InChI: 1S/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-15,18,22,26H,3-8,10-11H2,1-2H3/t14-,15-,18+,19-,20-,21-/m0/s1
• InChI 密鑰: MFYSYFVPBJMHGN-ZPOLXVRWSA-N
• 基因資訊: human ... SERPINA6(866)

描述

應用

Cortisone has been used:

• to validate a 1β-HSD1 (11β-hydroxysteroid dehydrogenase type 1) inhibitor
• to study the sensitivity of erythropoietic and granulopoietic progenitor cells to cortisone
• in the determination of rates of cortisol oxidation by 11βHSD

生化／生理作用

Cortisone (11 dehydro 17 hydroxycortico-sterone) is an anti-inflammatory glucocorticoid that delays wound healing after surgeries. It postpones the healing process by affecting the appearance of inflammatory cells, ground substance, fibroblasts, collagen, regenerating capillaries, and epithelial migration. Glucocorticoids have anti-inflammatory, anti-allergic and immunosuppressive properties and are extensively used in treatment and therapy.

Cortisone is a glucocorticoid; a corticosterone analog that has approximately twice the anti-inflammatory potency as corticosterone but much lower Na²⁺ retention potency.

包裝

Bottomless glass bottle. Contents are inside inserted fused cone.

安全資訊

• 象形圖: GHS08
• 訊號詞: Warning
• 危險聲明: H361d
• 防範說明: P201 - P202 - P280 - P308 + P313 - P405 - P501
• 危險分類: Repr. 2
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: Eyeshields, Gloves, type N95 (US)