推薦產品
化驗
≥98% (HPLC)
形狀
powder
顏色
white to beige
溶解度
DMSO: 2 mg/mL, clear
儲存溫度
2-8°C
生化／生理作用
吡唑酰胺Ceapin-A7是一种强效且高度特异性的ER应激诱导的ATF6α信号传导阻滞剂（通过基于HEK293T的ERSE-萤光素酶报告基因检测得出IC50 = 590 nM，U2OS细胞中ATF6α目标转录本GRP78/ERO1B/HERPUD1诱导的IC50 = 459/522/614 nM；由100 nM毒胡萝卜素所引起的ER应激），它不会影响未折叠蛋白应答（UPR）的IRE1或PERK分支，也不会影响与其紧密同源的ATF6β或SREBP的蛋白水解过程。Ceapin-A7可使U2-OS细胞对内质网应激诱导的死亡（在6 μM Ceapin-A7存在或不存在时的毒胡萝卜素EC50 = 4.5/7.1 nM）更加敏感，且不会影响未受应激细胞的活力。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
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