250401
细胞质动力蛋白抑制剂，Ciliobrevin D
Ciliobrevin D is a cell-permeable, reversible, and specific blocker of AAA+ ATPase motor cytoplasmic dynein. Disrupts spindle pole focusing and kinetochore-microtubule attachment (~10 to 40 µM).
同義詞:
细胞质动力蛋白抑制剂，Ciliobrevin D, 2-（7-氯-4-氧代-3,4-二氢喹唑啉-2（1H）-亚基）-3-（2,4-二氯苯基）-3-氧代丙腈，AAA+ ATPase运动细胞质动力蛋白抑制剂
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About This Item
推薦產品
品質等級
化驗
≥99% (HPLC)
形狀
powder
製造商／商標名
Calbiochem®
儲存條件
OK to freeze
protect from light
顏色
orange
溶解度
DMSO: 2.5 mg/mL
運輸包裝
ambient
儲存溫度
−20°C
SMILES 字串
O=C(C1=CC=C(Cl)C=C1N/2)NC2=C(C(C3=C(Cl)C=C(Cl)C=C3)=O)/C#N
一般說明
一种可渗透细胞的苯甲酰二氢喹唑啉酮衍生物，可作为AAA+ATPase运动细胞质动力蛋白的可逆和特异性阻滞剂，并以剂量依赖的方式破坏主轴极聚焦，冷稳定的微管形成，动粒微管附着和黑素体聚集（约10至40 µM）。 显示会干扰原纤毛内的蛋白运输，并导致原纤毛远端的鞭毛内运输蛋白88（IFT88）水平显著增加。据报道破坏了原纤毛依赖性Gli调节并阻断了刺猬信号传导。
包裝
用惰性气体包装
警告
毒性：标准处理（A）
重構
复溶后，等分并冷冻保存（-20°C）。储备液在-20°C条件下可稳定保存3个月。
法律資訊
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
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Science advances, 8(38), eabq8486-eabq8486 (2022-09-24)
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Eduardo D Gigante et al.
eLife, 9 (2020-03-05)
ARL13B is a regulatory GTPase highly enriched in cilia. Complete loss of Arl13b disrupts cilia architecture, protein trafficking and Sonic hedgehog signaling. To determine whether ARL13B is required within cilia, we knocked in a cilia-excluded variant of ARL13B (V358A) and
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