推薦產品
product name
细胞质动力蛋白抑制剂,Ciliobrevin D, Ciliobrevin D is a cell-permeable, reversible, and specific blocker of AAA+ ATPase motor cytoplasmic dynein. Disrupts spindle pole focusing and kinetochore-microtubule attachment (~10 to 40 µM).
品質等級
化驗
≥99% (HPLC)
形狀
powder
製造商/商標名
Calbiochem®
儲存條件
OK to freeze
protect from light
顏色
orange
溶解度
DMSO: 2.5 mg/mL
運輸包裝
ambient
儲存溫度
−20°C
SMILES 字串
O=C(C1=CC=C(Cl)C=C1N/2)NC2=C(C(C3=C(Cl)C=C(Cl)C=C3)=O)/C#N
一般說明
一种可渗透细胞的苯甲酰二氢喹唑啉酮衍生物,可作为AAA+ATPase运动细胞质动力蛋白的可逆和特异性阻滞剂,并以剂量依赖的方式破坏主轴极聚焦,冷稳定的微管形成,动粒微管附着和黑素体聚集(约10至40 µM)。 显示会干扰原纤毛内的蛋白运输,并导致原纤毛远端的鞭毛内运输蛋白88(IFT88)水平显著增加。据报道破坏了原纤毛依赖性Gli调节并阻断了刺猬信号传导。
包裝
用惰性气体包装
警告
毒性:标准处理(A)
重構
复溶后,等分并冷冻保存(-20°C)。储备液在-20°C条件下可稳定保存3个月。
法律資訊
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
儲存類別代碼
11 - Combustible Solids
水污染物質分類(WGK)
WGK 3
閃點(°F)
Not applicable
閃點(°C)
Not applicable
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號,寫有 ‘Lot’或‘Batch’.。
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