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Key Documents

SML2127

Sigma-Aldrich

地那唑

≥98% (HPLC)

同義詞:

2- [1-(4-氯苯基)-环丙基] -7-碘-5-氧代-4,5-二氢吡唑并[1,5-a]喹唑啉-3-碳酸酯

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About This Item

經驗公式(希爾表示法):
C20H12ClIN4O
CAS號碼:
分子量::
486.69
分類程式碼代碼:
12352200
NACRES:
NA.77

化驗

≥98% (HPLC)

形狀

powder

顏色

white to beige

溶解度

DMSO: 2 mg/mL, clear (warmed)

儲存溫度

2-8°C

SMILES 字串

IC1=CC=C(N2C(NC3=O)=C(C#N)C(C4(CC4)C5=CC=C(Cl)C=C5)=N2)C3=C1

生化/生理作用

Dynapyrazole-A是一种有效的动力蛋白抑制剂。Dynapyrazole-A可抑制微管活性,而不抑制基础ATPase活性。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

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Jonathan B Steinman et al.
eLife, 6 (2017-05-20)
Cytoplasmic dyneins are motor proteins in the AAA+ superfamily that transport cellular cargos toward microtubule minus-ends. Recently, ciliobrevins were reported as selective cell-permeable inhibitors of cytoplasmic dyneins. As is often true for first-in-class inhibitors, the use of ciliobrevins has in
Alexander S Zhovmer et al.
ACS nano, 15(11), 17528-17548 (2021-10-23)
Microtubules (MTs) and MT motor proteins form active 3D networks made of unstretchable cables with rod-like bending mechanics that provide cells with a dynamically changing structural scaffold. In this study, we report an antagonistic mechanical balance within the dynein-kinesin microtubular

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