推薦產品
產品名稱
SB-525334, ≥98% (HPLC)
品質等級
化驗
≥98% (HPLC)
形狀
solid
顏色
yellow
溶解度
DMSO: ≥20 mg/mL
起源
GlaxoSmithKline
儲存溫度
2-8°C
SMILES 字串
Cc1cccc(n1)-c2[nH]c(nc2-c3ccc4nccnc4c3)C(C)(C)C
InChI
1S/C21H21N5/c1-13-6-5-7-16(24-13)19-18(25-20(26-19)21(2,3)4)14-8-9-15-17(12-14)23-11-10-22-15/h5-12H,1-4H3,(H,25,26)
InChI 密鑰
DKPQHFZUICCZHF-UHFFFAOYSA-N
應用
SB-525334已被用于研究TGFβ1介导的人滋养细胞分化。7
生化／生理作用
SB-525334在肾近端小管细胞中可阻断TGFβ1诱导的Smad2/3的激活。4 SB-525334可降低TGFβ1的敏感性，从而通过逆转肺动脉压而有益于肺动脉高血压。5 SB-525334可降低子宫平滑肌瘤等间充质肿瘤的发生率和大小。6
SB-525334是一种有效的激活素受体样激酶（ALK5）/I型TGFβ-受体激酶抑制剂，其 IC50 = 14.3 nM。
特點和優勢
该化合物由GlaxoSmithKline开发。要浏览其他药物开发化合物和批准的药物/候选药物列表，单击此处。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
個人防護裝備
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
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我們的科學家團隊在所有研究領域都有豐富的經驗，包括生命科學、材料科學、化學合成、色譜、分析等.
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