SML1614

Rp-8-Br-cGMPS sodium salt

≥98% (HPLC)

• 同義詞: Rp-8-Bromo-cGMPS sodium salt, Rp-8-Bromoguanosine- 3′, 5′- cyclic monophosphorothioate sodium salt
• 經驗公式（希爾表示法）: C₁₀H₁₀BrN₅O₆PS · Na
• CAS號碼: 208445-06-1
• 分子量：: 462.15
• MDL號碼: MFCD04037242
• 分類程式碼代碼: 12352200
• PubChem物質ID: 329825500
• NACRES: NA.77

屬性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: lyophilized solid
• 顏色: white to beige
• 儲存溫度: −20°C
• SMILES 字串: O=C1C2=C(N([C@@H]3O[C@H](CO[P@@](O4)([O-])=S)[C@@H]4[C@H]3O)C(Br)=N2)N=C(N)N1.[Na+]
• InChI: 1S/C10H11BrN5O6PS.Na/c11-9-13-3-6(14-10(12)15-7(3)18)16(9)8-4(17)5-2(21-8)1-20-23(19,24)22-5;/h2,4-5,8,17H,1H2,(H,19,24)(H3,12,14,15,18);/q;+1/p-1/t2-,4-,5-,8-,23-;/m1./s1
• InChI 密鑰: CHTSSROWUAICIL-GMKUFTCMSA-M

描述

生化／生理作用

Rp-8-bromo-cGMPS is a cell permeable cGMP analog that blocks cGMP-dependent protein kinase (cGK, G-kinase, Protein Kinase G, PKG). Rp-8-bromo-cGMPS is resistant to hydrolysis by phosphodiesterases and binds cGK without activating it, resulting in competitive inhibition.

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable