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Key Documents

B6684

Sigma-Aldrich

Rp-8-溴-β-苯基-1,N2-乙鸟苷3′,5′-环硫代磷酸酯 钠盐

≥98% (HPLC), powder

同義詞:

Rp- β-苯基-1,N 2-etheno-8-溴鸟苷3 ′,5′-环一硫代磷酸酯 钠盐, Rp-8-Br-PET-cGMPS

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About This Item

經驗公式(希爾表示法):
C18H14BrN5NaO6PS
CAS號碼:
分子量::
562.27
分類程式碼代碼:
41106305
PubChem物質ID:
NACRES:
NA.77

品質等級

化驗

≥98% (HPLC)

形狀

powder

效力

30 nM Ki

顏色

white to beige

mp

240-300 °C (lit.)

溶解度

H2O: 15 mg/mL at ≤60 °C

儲存溫度

−20°C

SMILES 字串

O.[Na+].O[C@@H]1[C@@H]2O[P@]([O-])(=S)OC[C@H]2O[C@H]1n3c(Br)nc4C(=O)n5cc(nc5Nc34)-c6ccccc6

InChI

1S/C18H15BrN5O6PS.Na/c19-17-21-11-14(24(17)16-12(25)13-10(29-16)7-28-31(27,32)30-13)22-18-20-9(6-23(18)15(11)26)8-4-2-1-3-5-8;/h1-6,10,12-13,16,25H,7H2,(H,20,22)(H,27,32);/q;+1/p-1/t10-,12-,13-,16-,31-;/m1./s1

InChI 密鑰

SVMPQLHYWRTQCX-DBHVCDLJSA-M

生化/生理作用

Rp-8-Br-PET-cGMPS是cGMP依赖性蛋白激酶G的代谢稳定的竞争性抑制剂。可抑制PKG I(K= 30 nM)和PKG II,阻断cGMP门控视网膜离子通道(IC50 = 25 μM)。

特點和優勢

《受体分类和信号转导》手册的PKA & PKG页有该化合物的介绍。想要浏览手册的其他页面, 请单击此处

法律資訊

美国专利5,625,056,德国专利4,217,679。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


分析證明 (COA)

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