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Merck
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Key Documents

SML1489

Sigma-Aldrich

FICZ

≥95% (HPLC), lyophilized powder, AhR agonist

同義詞:

5,11-二氢-吲哚[3,2-b] 咔唑-6-甲醛, 6-甲酰吲哚[3,2-b] 咔唑

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About This Item

經驗公式（希爾表示法）:
C19H12N2O
CAS號碼:
172922-91-7
分子量：:
284.31
分類程式碼代碼:
12352200
NACRES:
NA.77

product name

FICZ, ≥95% (HPLC)

品質等級

100

化驗

≥95% (HPLC)

形狀

lyophilized powder

顏色

yellow

溶解度

DMSO: 0.5 mg/mL, clear (warmed)

儲存溫度

−20°C

生化／生理作用

FICZ 是芳香烃受体 (aryl hydrocarbon receptor,AhR) 的强效高亲和力配体，是一种配体激活的转录因子，可激活 CYP1A1 基因等芳香烃代谢酶基因的表达，也被证明在细胞周期调控、许多组织的发育成熟、控制炎症和免疫反应中具有多种额外的作用。FICZ 是色氨酸的光产物，被认为是内源性 AhR 配体。其效力极强，Kd 值为 0.07 nM。
FICZ（6-甲酰吲哚 (3,2b) 咔唑）是色氨酸的光氧化产物，可能作为光的化学信使。

象形圖

Exclamation mark
GHS07

訊號詞

Warning

危險聲明

H302

危險分類

Acute Tox. 4 Oral

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 1

閃點（°F）

Not applicable

閃點（°C）

Not applicable

分析證明 (COA)

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