推薦產品
product name
CH-223191,
化驗
≥98% (HPLC)
品質等級
形狀
powder
顏色
orange-brown
溶解度
DMSO: ≥20 mg/mL
儲存溫度
2-8°C
SMILES 字串
Cc1cc(ccc1NC(=O)c2ccnn2C)\N=N\c3ccccc3C
InChI
1S/C19H19N5O/c1-13-6-4-5-7-17(13)23-22-15-8-9-16(14(2)12-15)21-19(25)18-10-11-20-24(18)3/h4-12H,1-3H3,(H,21,25)/b23-22+
InChI 密鑰
LKTNEXPODAWWFM-GHVJWSGMSA-N
應用
CH-223191已被用作肝素细胞、TH17-白细胞介素-10+细胞和有机类中的芳香烃受体（AHR）拮抗剂。
生化／生理作用
CH-223191是一种强效特异性芳香烃受体（AhR）拮抗剂。它抑制TCDD介导的核转位和AhR的脱氧核糖核酸结合，并抑制TCDD诱导的荧光素酶活性，IC50为30纳米。与其他在高浓度下显示激动剂活性的AhR拮抗剂不同，CH-223191即使在100微摩尔时也不能刺激AhR依赖性转录。它也对AhR有特异性，对雌激素受体没有亲和力，就像其他拮抗剂一样。
特點和優勢
该化合物在受体分类和信号转导手册中 核受体（非甾体化合物） 页面中进行了详细介绍。欲浏览其他手册页面，请 点击这里。
这种化合物是基因调控研究的特色产品。点击此处发现更多特色基因调控产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
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