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Sigma-Aldrich

1-氯-2,4-二硝基苯

≥99%

同義詞:

2,4-二硝基氯苯, CDNB, DNCB

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About This Item

線性公式:
ClC6H3(NO2)2
CAS號碼:
97-00-7
分子量：:
202.55
Beilstein:
613161
EC號碼:
202-551-4
MDL號碼:
MFCD00007075
分類程式碼代碼:
12352100
PubChem物質ID:
24854237
NACRES:
NA.22

品質等級

200

化驗

≥99%

形狀

solid

expl. lim.

22 %

bp

315 °C (lit.)

mp

48-50 °C (lit.)

溶解度

alcohol: very slightly soluble (cold)(lit.)
benzene: soluble(lit.)
carbon disulfide: soluble(lit.)
diethyl ether: soluble(lit.)
water: insoluble (practically)(lit.)

SMILES 字串

[O-][N+](=O)c1ccc(Cl)c(c1)[N+]([O-])=O

InChI

1S/C6H3ClN2O4/c7-5-2-1-4(8(10)11)3-6(5)9(12)13/h1-3H

InChI 密鑰

VYZAHLCBVHPDDF-UHFFFAOYSA-N

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相關類別

一般說明

与红细胞孵育的1-氯-2,4-二硝基苯可与红细胞谷胱甘肽（GSH）结合，以形成2,4-二硝基苯基-S-谷胱甘肽。它是一种人体硫氧还蛋白还原酶的不可逆抑制剂。

應用

1-氯-2,4-二硝基苯已被用作烷化剂，以对细胞内红细胞谷胱甘肽（GSH）的消耗进行评估。

訊號詞

Danger

危險分類

Acute Tox. 2 Dermal - Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Skin Irrit. 2 - Skin Sens. 1

儲存類別代碼

6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials

水污染物質分類（WGK）

WGK 2

閃點（°F）

381.2 °F - closed cup

閃點（°C）

194 °C - closed cup

個人防護裝備

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

分析證明 (COA)

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Y C Awasthi et al.
Blood, 58(4), 733-738 (1981-10-01)
Erythrocyte glutathione (GSH) can be rapidly depleted by incubating the cells with 1-chloro-2,4-dinitrobenzene (CDNB), which forms 2,4-dinitrophenyl-S-glutathione with GSH through the reaction catalyzed by glutathione S-transferase. GSH-CDNB conjugate thus formed stays undegraded within the erythrocytes. This indicates that in the
E S Arnér et al.
The Journal of biological chemistry, 270(8), 3479-3482 (1995-02-24)
Human thioredoxin reductase is a dimeric enzyme that catalyzes reduction of the disulfide in oxidized thioredoxin by a mechanism involving transfer of electrons from NADPH via FAD to a redox-active disulfide. 1-Chloro-2,4-dinitrobenzene (DNCB) is an alkylating agent used for depleting
Jochem W van der Veen et al.
Archives of toxicology, 87(4), 763-766 (2012-11-13)
Several in vitro DNA microarray studies have shown the importance of nuclear factor (erythroid-derived 2)-like 2 (Nrf2) in skin sensitization. Nevertheless, the exact in vivo role of the Nrf2-Keap1 pathway during the induction of skin sensitization remains unknown. To study
R Li et al.
Allergy, 67(10), 1250-1258 (2012-08-23)
We previously reported that prior nasal administration of highly attenuated Bordetella pertussis BPZE1 provides effective and sustained protection against lethal challenge with influenza A viruses. The protective effect was mediated by suppressing the production of major pro-inflammatory mediators. To further
Xiaoxiao Peng et al.
The Biochemical journal, 447(1), 167-174 (2012-07-13)
Thiophosphate (SPO(3)) was recently shown to promote cysteine insertion at Sec (selenocysteine)-encoding UGA codons during selenoprotein synthesis. We reported previously that irreversible targeting by cDDP [cis-diamminedichloroplatinum(II) or cisplatin] of the Sec residue in TrxR1 (thioredoxin reductase 1) contributes to cDDP
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