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Merck
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文件

SML0784

Sigma-Aldrich

BMS-303141

≥98% (HPLC)

同義詞:

3,5-二氯-2-羟基-N-(4-甲氧基[1,1'-联苯]-3-基)苯磺酰胺

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About This Item

經驗公式(希爾表示法):
C19H15Cl2NO4S
CAS號碼:
分子量::
424.30
MDL號碼:
分類程式碼代碼:
51111800
NACRES:
NA.77

品質等級

化驗

≥98% (HPLC)

形狀

powder

顏色

white to beige

溶解度

DMSO: 20 mg/mL, clear

儲存溫度

2-8°C

SMILES 字串

O=S(NC1=C(OC)C=CC(C2=CC=CC=C2)=C1)(C3=C(O)C(Cl)=CC(Cl)=C3)=O

InChI

1S/C19H15Cl2NO4S/c1-26-17-8-7-13(12-5-3-2-4-6-12)9-16(17)22-27(24,25)18-11-14(20)10-15(21)19(18)23/h2-11,22-23H,1H3

InChI 密鑰

SIIPNDKXZOTLEA-UHFFFAOYSA-N

應用

BMS-303141已被用于抑制乳腺癌细胞系中的ATP柠檬酸裂合酶。

生化/生理作用

BMS-303141是ATP柠檬酸裂解酶(ACL)的一种有效抑制剂。 BMS-303141可抑制HepG2细胞中的脂质合成,IC50值为8μM。同时,在鼠高脂血症模型中,其可降低血浆中的甘油三酸酯的含量。

危險聲明

防範說明

危險分類

Aquatic Chronic 4

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

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