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347795

Sigma-Aldrich

二氯乙酸钠

98%

同義詞:

二氯乙酸 钠盐

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About This Item

線性公式:
Cl2CHCO2Na
CAS號碼:
2156-56-1
分子量：:
150.92
EC號碼:
218-461-3
MDL號碼:
MFCD00070489
分類程式碼代碼:
12352302
PubChem物質ID:
24861527
NACRES:
NA.22

品質等級

100

化驗

98%

雜質

<2% ethyl alcohol

mp

198 °C (dec.) (lit.)

SMILES 字串

[Na+].[O-]C(=O)C(Cl)Cl

InChI

1S/C2H2Cl2O2.Na/c3-1(4)2(5)6;/h1H,(H,5,6);/q;+1/p-1

InChI 密鑰

LUPNKHXLFSSUGS-UHFFFAOYSA-M

基因資訊

human ... PDK1(5163) , PDK2(5164) , PDK3(5165) , PDK4(5166)

相關類別

一般說明

二氯乙酸钠是一种线粒体丙酮酸脱氢酶激酶（PDK）抑制剂，具有强大的抗白血病活性。

應用

二氯乙酸钠可用作合成微孔碳的有机盐前体，其可用于开发碳基吸附剂。

其他說明

2024年CiteAb奖，授予在帕金森研究方面取得成功的供应商

象形圖

Health hazardExclamation mark
GHS08,GHS07

訊號詞

Warning

危險分類

Carc. 2 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 2

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves

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分析證明 (COA)

Lot/Batch Number
STBK2573
STBK0770
STBJ8996
STBJ4103
STBJ0423

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Preparing microporous carbon from solid organic salt precursors using in situ templating and a fixed-bed reactor.
Atkinson JD & Rood MJ.
Microporous and Mesoporous Materials : The Official Journal of the International Zeolite Association, 160, 174-181 (2012)
Marie-Aline Neveu et al.
Oncotarget, 7(49), 81741-81749 (2017-01-14)
Reverting glycolytic metabolism is an attractive strategy for cancer therapy as upregulated glycolysis is a hallmark in various cancers. Dichloroacetate (DCA), long used to treat lactic acidosis in various pathologies, has emerged as a promising anti-cancer drug. By inhibiting the
Mito-DCA: a mitochondria targeted molecular scaffold for efficacious delivery of metabolic modulator dichloroacetate.
Pathak RK, et al.
ACS Chemical Biology, 9(5), 1178-1187 (2014)
Mario Ammendola et al.
Scientific reports, 10(1), 6521-6521 (2020-04-18)
The growing interest of oncologists in natural compounds such as polyphenols and flavonoids is encouraging the development of innovative and efficient carriers for the delivery of those drugs. This study examines carboxymethyl chitosan-based microcapsules created by spray drying as a
Han Shen et al.
Molecular cancer therapeutics, 14(8), 1794-1804 (2015-06-13)
Because radiotherapy significantly increases median survival in patients with glioblastoma, the modulation of radiation resistance is of significant interest. High glycolytic states of tumor cells are known to correlate strongly with radioresistance; thus, the concept of metabolic targeting needs to
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