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Key Documents

SAB4502019

Sigma-Aldrich

Anti-NOTCH1 (Cleaved-Val1754) antibody produced in rabbit

affinity isolated antibody

同義詞:

NOTC1, Notch homolog 1, neurogenic locus notch 1, notch 1 (translocation-associated), translocation-associated (Drosophila) (TAN1)

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About This Item

分類程式碼代碼:
12352203
NACRES:
NA.41

生物源

rabbit

共軛

unconjugated

抗體表格

affinity isolated antibody

抗體產品種類

primary antibodies

無性繁殖

polyclonal

形狀

buffered aqueous solution

分子量

antigen 110 kDa

物種活性

rat, mouse, human

濃度

~1 mg/mL

技術

ELISA: 1:5000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

NCBI登錄號

UniProt登錄號

應用

research pathology

運輸包裝

wet ice

儲存溫度

−20°C

目標翻譯後修改

proteolytically cleaved (Val1754)

基因資訊

human ... NOTCH1(4851)

相關類別

一般說明

The NOTCH1 gene is mapped to human chromosome 9q34 and encodes a member of the NOTCH family of proteins. The gene encodes a large transmembrane protein that contains an extracellular domain with 36 tandem epidermal growth factor (EGF)-like repeats and three cysteine-rich Notch/LIN-12 repeats, a six ankyrin repeat-containing intracellular domain, and a transactivation domain.

Anti-NOTCH1 (Cleaved-Val1754) Antibody detects endogenous levels of fragment of activated NOTCH1 (Cleaved-Val1754) protein.

免疫原

The antiserum was produced against synthesized peptide derived from human Notch 1.

Immunogen Range: 1735-1784

應用

Anti-NOTCH1 (Cleaved-Val1754) antibody produced in rabbit has been used in immunohistochemistry (IHC).

生化/生理作用

The Notch1 protein is a transmembrane receptor that induces pluripotent progenitor cells to form T-cells and facilitates the assembly of pre–T cell receptor complexes in immature thymocytes. It participates in an intracellular signaling pathway that regulates cellular differentiation, cell fate and lateral inhibition. Mutations in this gene have been associated with human blood cancers, abnormal cardiovascular calcification, aortic valve disease, and human T cell acute lymphoblastic leukemia.

特點和優勢

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

外觀

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

nwg

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

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您可以在文件庫中找到最近購買的產品相關文件。

存取文件庫

Notch 1 is a valuable therapeutic target against cell survival and proliferation in clear cell renal cell carcinoma.
Zhuang Z, et al.
Oncology Letters, 14(3), 3437-3444 (2017)
Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia.
Weng A P, et al.
Science, 306(5694), 269-271 (2004)
Mutations in NOTCH1 cause aortic valve disease.
Garg V, et al.
Nature, 437(7056), 270-270 (2005)
Yan Li et al.
Bioengineered, 12(2), 10183-10193 (2021-12-08)
As the second most common cancer among women, cervical cancer is a huge threat to their health all over the world. Integral membrane protein 2A (ITM2A), a member of the Type II Integral Membrane protein (ITM2) family, has been reported
Yu-Wen Cao et al.
International journal of clinical and experimental pathology, 7(7), 4286-4294 (2014-08-15)
Accumulated evidence has revealed the presence of Notch receptor polymorphisms in non-tumorous diseases; however, few studies have investigated the association of Notch polymorphisms with breast cancer risk. A total of 100 invasive ductal carcinoma (IDC) and 50 ductal carcinoma in

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