SAB4502986

Anti-C1QB, C-Terminal antibody produced in rabbit

affinity isolated antibody

• 同義詞: Complement C1q subcomponent subunit B
• 分類程式碼代碼: 12352203
• NACRES: NA.41

屬性

• 生物源: rabbit
• 品質等級: 100
• 共軛: unconjugated
• 抗體表格: affinity isolated antibody
• 抗體產品種類: primary antibodies
• 無性繁殖: polyclonal
• 形狀: buffered aqueous solution
• 分子量: antigen 26 kDa
• 物種活性: human
• 濃度: ~1 mg/mL
• 技術: ELISA: 1:40000; immunofluorescence: 1:100-1:500; western blot: 1:500-1:1000
• NCBI登錄號: P02746
• UniProt登錄號: P02746
• 運輸包裝: wet ice
• 儲存溫度: −20°C
• 目標翻譯後修改: unmodified
• 基因資訊: human ... C1QB(713)

描述

一般說明

Anti-C1QB Antibody detects endogenous levels of total C1QB protein.

The C1QB (complement C1q B chain) gene is mapped to human chromosome 1p36.12 and codes for the subcomponent of C1q protein, which is part of C1 complex of the classical pathway. The encoded protein is predominantly expressed in neurons and glia. It is localized to the growing synapses. The encoded protein is a hexameric molecule consisting of three distinct types of 18 polypeptide chains.

免疫原

The antiserum was produced against synthesized peptide derived from human C1QB.

Immunogen Range: 161-210

生化／生理作用

The protein encoded by C1QB (complement C1q B chain) gene is involved in synapse formation and offers neuroprotection in the central nervous system. In response to a number of immune and nonimmune ligands, C1q protein activates proteases C1r and C1s in order to trigger classical complement pathway. C1q protein is regarded as a major component of the humoral innate immune defense. C1q carries out opsonophagocytosis, inflammation, and cytolysis to eliminate pathogenic microorganism and harmful apoptotic cells. Mutations in the gene causes systemic lupus erythematosus. Variation in the gene is also linked to rheumatoid schizophrenia, arthritis, amyloidotic polyneuropathy, metastasis of cancer.

特點和優勢

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外觀

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全資訊

• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: nwg
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable