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Merck
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重要文件

SAB4502021

Sigma-Aldrich

Anti-NOTCH2 (Cleaved-Ala1734) antibody produced in rabbit

affinity isolated antibody

同義詞:

Motch B, NOTC2, NOTCH2, NTC2, Neurogenic locus notch homolog protein 2 precursor

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About This Item

分類程式碼代碼:
12352203
NACRES:
NA.41
共軛:
unconjugated
application:
ELISA
WB
無性繁殖:
polyclonal
物種活性:
rat, mouse, human
citations:
4
技術:
ELISA: 1:10000
western blot: 1:500-1:1000

生物源

rabbit

品質等級

共軛

unconjugated

抗體表格

affinity isolated antibody

抗體產品種類

primary antibodies

無性繁殖

polyclonal

形狀

buffered aqueous solution

分子量

antigen 79 kDa

物種活性

rat, mouse, human

濃度

~1 mg/mL

技術

ELISA: 1:10000
western blot: 1:500-1:1000

NCBI登錄號

UniProt登錄號

運輸包裝

wet ice

儲存溫度

−20°C

目標翻譯後修改

proteolytically cleaved (Ala1734)

基因資訊

human ... NOTCH2(4853)

相關類別

一般說明

The NOTCH2 (notch 2) gene is mapped to human chromosome 1p12. Anti-NOTCH2 (cleaved-Ala1734) antibody detects endogenous levels of fragment of activated NOTCH2 (cleaved-Ala1734) protein.

免疫原

The antiserum was produced against synthesized peptide derived from human NOTCH2.

Immunogen Range: 1715-1764

生化/生理作用

The NOTCH2 (notch2) gene is known to be involved in the proliferation and cell cycle progression in cancer cells. Upregulation of the gene is observed in salivary adenoid cystic carcinoma, and hepatocellular carcinoma. Deletion of NOTCH2 offers tumor cells resistance to chemotherapeutic agents such as 5-fluorouracil. NOTCH2 plays an important role in the regulation of liver development. The NOTCH2 gene is associated with the development of diabetic nephropathy.

特點和優勢

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

外觀

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

nwg

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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分析證明 (COA)

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存取文件庫

Altered expression of WFS1 and NOTCH2 genes associated with diabetic nephropathy in T2DM patients
Sharaf SA, et al.
Diabetes Research and Clinical Practice, 140, 304-313 (2018)
Notch2 is a crucial regulator of self-renewal and tumorigenicity in human hepatocellular carcinoma cells
Wu WR, et al.
Oncology Reports, 36(1), 181-188 (2016)
NOTCH2 mutations cause Alagille syndrome, a heterogeneous disorder of the notch signaling pathway
McDaniell R, et al.
American Journal of Human Genetics, 79(1), 169-173 (2006)
Jing Qu et al.
Molecular and cellular biochemistry, 411(1-2), 135-141 (2015-10-03)
Many studies have explored whether the Notch signaling pathway has a tumor-suppressive or an oncogenic role in various tumors; however, the role of the Notch signaling pathway in salivary adenoid cystic carcinoma (SACC) is still unknown. In this study, we
Arjan J Groot et al.
Molecular and cellular biology, 34(15), 2822-2832 (2014-05-21)
In mammals, there are four NOTCH receptors and five Delta-Jagged-type ligands regulating many aspects of embryonic development and adult tissue homeostasis. NOTCH proteins are type I transmembrane receptors that interact with ligands on adjacent cells and are activated by regulated

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