跳轉至內容
Merck
全部照片(1)

Key Documents

R8279

Sigma-Aldrich

RG108

≥98% (HPLC), powder

同義詞:

N-酞酰-L-色氨酸

登入查看組織和合約定價


About This Item

經驗公式(希爾表示法):
C19H14N2O4
CAS號碼:
分子量::
334.33
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77

品質等級

化驗

≥98% (HPLC)

形狀

powder

光學活性

[α]/D -250 to -310°, c = 0.5 in methanol

顏色

yellow

溶解度

DMSO: >10 mg/mL

儲存溫度

−20°C

SMILES 字串

OC(=O)[C@H](Cc1c[nH]c2ccccc12)N3C(=O)C4=CCCC=C4C3=O

InChI

1S/C19H16N2O4/c22-17-13-6-1-2-7-14(13)18(23)21(17)16(19(24)25)9-11-10-20-15-8-4-3-5-12(11)15/h3-8,10,16,20H,1-2,9H2,(H,24,25)/t16-/m0/s1

InChI 密鑰

LMAZUAXDZRILNJ-INIZCTEOSA-N

一般說明

RG108是一种非核苷类似物,也称为[2-(1,3-二氧异吲哚啉-2-基)-3-(1H-吲哚-3-基)丙酸。

應用

RG108可用于:
  • 重编程和提高原代多能间充质干细胞 (MMSC) 的可塑性。
  • 作为人视网膜色素上皮细胞ARPE-19中的DNA甲基转移酶抑制剂 (DNMTi)。
  • 作为C33A2细胞的DNA甲基转移酶抑制剂,检测其对乳头瘤病毒晚期基因表达 (HPV16) 的影响。

生化/生理作用

RG108是一种DNA甲基转移酶(DMNT)抑制剂。它通过DNA去甲基化重新激活肿瘤细胞中的肿瘤抑制基因表达(p16,SFRP1,分泌性卷曲相关蛋白-1和TIMP-3)。RG108还能抑制人肿瘤细胞系(HCT116,NALM-6)增殖并增加培养的倍增时间。
Rg108的细胞毒性低于氮杂胞苷 (5-Aza-dCR)。它介导食道癌细胞 (EC) 的辐射敏感性。RG108是有效的表观遗传调控剂和去甲基化剂。它不会引起细胞毒性,可用于基于人骨髓间充质干细胞 (hBMSC) 的干细胞治疗。它作用于DNA甲基转移酶1的催化结构域。

特點和優勢

这种化合物是基因调控研究的特色产品。点击此处发现更多特色基因调控产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號,寫有 ‘Lot’或‘Batch’.。

已經擁有該產品?

您可以在文件庫中找到最近購買的產品相關文件。

存取文件庫

Xiong Liu et al.
Cellular signalling, 51, 243-256 (2018-08-20)
It is well known that epithelial-mesenchymal transition (EMT) can confer cancer cells with invasive and migratory capabilities associated with distant metastasis. As a key upstream factor in the Hippo pathway, Kibra (wwc1 gene) has been shown to suppress EMT in
Stephanie Bridgeman et al.
Cancers, 11(4) (2019-04-13)
The potential anticancer effects of statins-a widely used class of cholesterol lowering drugs-has generated significant interest, as has the use of epigenetic modifying drugs such as HDAC and DNMT inhibitors. We set out to investigate the effect of statin drugs
Lucia Bialesova et al.
Scientific reports, 7(1), 10152-10152 (2017-09-02)
Increased adipocyte lipolysis links obesity to insulin resistance. The lipid droplet coating-protein Perilipin participates in regulation of lipolysis and is implicated in obesity. In the present study we investigate epigenetic regulation of the PLIN1 gene by correlating PLIN1 CpG methylation
German Todorov et al.
Scientific reports, 9(1), 8741-8741 (2019-06-21)
Mental health disorders are manifested in families, yet cannot be fully explained by classical Mendelian genetics. Changes in gene expression via epigenetics present a plausible mechanism. Anxiety often leads to avoidant behaviors which upon repetition may become habitual, maladaptive and
Peter Karagiannis et al.
Physiological reviews, 99(1), 79-114 (2018-10-18)
The discovery of somatic cell nuclear transfer proved that somatic cells can carry the same genetic code as the zygote, and that activating parts of this code are sufficient to reprogram the cell to an early developmental state. The discovery

我們的科學家團隊在所有研究領域都有豐富的經驗,包括生命科學、材料科學、化學合成、色譜、分析等.

聯絡技術服務