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Key Documents

A5282

Sigma-Aldrich

DL-2-氨基-5-膦酰戊酸

≥98% (TLC), solid, NMDA receptor antagonist

同義詞:

5-膦酰基-DL-正缬氨酸, DL-2-氨基-5-膦酰基缬草酸, AP-5, APV

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About This Item

經驗公式(希爾表示法):
C5H12NO5P
CAS號碼:
分子量::
197.13
Beilstein:
2446389
MDL號碼:
分類程式碼代碼:
12352106
PubChem物質ID:
NACRES:
NA.32

product name

DL-2-氨基-5-膦酰戊酸, solid

形狀

solid

顏色

white

溶解度

0.1 M NaOH: 4 mg/mL
H2O: 5.6 mg/mL
organic solvents: insoluble

SMILES 字串

NC(CCCP(O)(O)=O)C(O)=O

InChI

1S/C5H12NO5P/c6-4(5(7)8)2-1-3-12(9,10)11/h4H,1-3,6H2,(H,7,8)(H2,9,10,11)

InChI 密鑰

VOROEQBFPPIACJ-UHFFFAOYSA-N

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應用

DL-2-氨基-5-膦酰戊酸已用于:
  • N-甲基-D-天冬氨酸(NMDA)介导突触灭活
  • 用于生长培养基用于抑制神经元网络的电活性
  • 用于分离N-甲基-D-天冬氨酸受体(NMDAR)或α-氨基-3-羟基-5-甲基-4-异噁唑丙酸受体(AMPAR)介导电流
  • 溶于双蒸水中,与朊蛋白(PrPC)比较其NMDA拮抗作用

生化/生理作用

镇痉;有效的选择性NMDA受体拮抗剂。

注意

吸湿

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


分析證明 (COA)

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Shein M, et al.
Biomedical Microdevices, 11(2), 495-501 (2009)
Activation of NR2A-containing NMDA receptors is not obligatory for NMDA receptor-dependent long-term potentiation
Weitlauf C, et al.
The Journal of Neuroscience, 25(37), 8386-8390 (2005)
Ryota Kobayashi et al.
Frontiers in computational neuroscience, 3, 9-9 (2009-08-12)
Information is transmitted in the brain through various kinds of neurons that respond differently to the same signal. Full characteristics including cognitive functions of the brain should ultimately be comprehended by building simulators capable of precisely mirroring spike responses of
Maria José Diógenes et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 32(34), 11750-11762 (2012-08-24)
Parkinson's disease (PD) is the most common representative of a group of disorders known as synucleinopathies, in which misfolding and aggregation of α-synuclein (a-syn) in various brain regions is the major pathological hallmark. Indeed, the motor symptoms in PD are
Marijn van Wingerden et al.
Neuron, 76(4), 813-825 (2012-11-28)
Neural activity in orbitofrontal cortex has been linked to flexible representations of stimulus-outcome associations. Such value representations are known to emerge with learning, but the neural mechanisms supporting this phenomenon are not well understood. Here, we provide evidence for a

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