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Merck
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重要文件

A8054

Sigma-Aldrich

D(-)-2-氨基-5-膦戊酸

NMDA receptor antagonist

同義詞:

D -2-氨基-5-膦酰戊酸, D(-)-AP-5, D(-)-APV

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About This Item

經驗公式(希爾表示法):
C5H12NO5P
CAS號碼:
分子量::
197.13
MDL號碼:
分類程式碼代碼:
12352106
PubChem物質ID:
NACRES:
NA.26

化驗

≥98% (TLC)

形狀

powder

光學純度

optical purity: ≥90% (HPLC, Marfey′s reagent)

技術

ligand binding assay: suitable

顏色

white

mp

245-246 °C

SMILES 字串

N[C@H](CCCP(O)(O)=O)C(O)=O

InChI

1S/C5H12NO5P/c6-4(5(7)8)2-1-3-12(9,10)11/h4H,1-3,6H2,(H,7,8)(H2,9,10,11)/t4-/m1/s1

InChI 密鑰

VOROEQBFPPIACJ-SCSAIBSYSA-N

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應用

D (-)-2-氨基-5-膦戊酸已被用于预处理 BNST(终纹床核),以阻止 ORX-A(食欲素-A)引入 BNST 的焦虑。

生化/生理作用

NMDA 拮抗剂具有肌肉松弛属性,对缺血引起的脑损伤具有神经元保护作用。2-氨基-5-膦甲酸已被证明可以阻断离子导入引起的 NMDA 的去极化。
抗惊厥药;强效和选择性N-甲基-D-天冬氨酸 (NMDA) 受体拮抗剂;2-氨基-5-膦酰戊酸的活性对映体。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


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