推薦產品
產品名稱
3′-叠氮-3′-脱氧胸苷, ≥98% (HPLC)
品質等級
化驗
≥98% (HPLC)
形狀
powder
mp
113-115 °C (lit.)
溶解度
H2O: 50 mg/mL
儲存溫度
−20°C
SMILES 字串
CC1=CN([C@H]2C[C@H](N=[N+]=[N-])[C@@H](CO)O2)C(=O)NC1=O
InChI
1S/C10H13N5O4/c1-5-3-15(10(18)12-9(5)17)8-2-6(13-14-11)7(4-16)19-8/h3,6-8,16H,2,4H2,1H3,(H,12,17,18)/t6-,7+,8+/m0/s1
InChI 密鑰
HBOMLICNUCNMMY-XLPZGREQSA-N
基因資訊
human ... HIVE1(3095)
mouse ... Slc29a1(63959)
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應用
3′-叠氮-3′-脱氧胸苷已作为逆转录酶抑制剂抑制病毒基因组整合和作为抗菌剂评估其抗沙门氏菌活性。
生化／生理作用
叠氮胸苷 (AZT) 是一种胸苷类似物，是 HIV-1 病毒的逆转录酶抑制剂。叠氮胸苷已被证明会降低 CRISPR 介导的同源定向修复 (HDR) 的效率。
对 HIV-1 病毒有效的逆转录酶抑制剂。
特點和優勢
这种化合物是ADME毒性研究的特色产品。点击此处发现更多特色ADME毒性产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
訊號詞
Warning
危險聲明
危險分類
Carc. 2 - Muta. 2
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
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文章
The CRISPR-Cas9 system is an RNA-guided genome-editing tool that provides researchers a simple, easy, and quick way to modify the genomes of various organisms.
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