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重要文件

189825

Sigma-Aldrich

5-氮杂-2′-脱氧胞苷酸

A cytosine analog that acts as a DNA methyltransferase inhibitor.

同義詞:

5-氮杂-2′-脱氧胞苷酸, 5-Aza-CdR,5-Aza-dC,2′-脱氧-5-氮杂胞苷,地西他滨

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About This Item

經驗公式(希爾表示法):
C8H12N4O4
CAS號碼:
分子量::
228.21
MDL號碼:
分類程式碼代碼:
12352208
NACRES:
NA.77

品質等級

描述

RTECS - XZ3012000

化驗

≥98% (HPLC)

形狀

lyophilized

製造商/商標名

Calbiochem®

儲存條件

OK to freeze

溶解度

methanol: 1 mg/mL
50% acetic acid: 25 mg/mL
DMSO: 25 mg/mL

運輸包裝

ambient

儲存溫度

2-8°C

SMILES 字串

N2(C=NC(=N)NC2=O)C1OC(C(C1)O)CO

InChI

1S/C8H12N4O4/c9-7-10-3-12(8(15)11-7)6-1-4(14)5(2-13)16-6/h3-6,13-14H,1-2H2,(H2,9,11,15)

InChI 密鑰

XAUDJQYHKZQPEU-UHFFFAOYSA-N

一般說明

一种作为DNA甲基转移酶抑制剂的胞嘧啶类似物。在TRAIL抗性细胞系中恢复caspase-8和caspase-10 mRNA和蛋白表达以及TRAIL(肿瘤坏死因子相关凋亡诱导配体)敏感性。也增强HDAC(组蛋白去乙酰化酶)抑制剂诱导的凋亡。也可以提供100 mM的DMSO溶液(目录号189826)。

生化/生理作用

主要靶标
DNA甲基转移酶抑制剂

包裝

用惰性气体包装

警告

毒性:有害 & 致癌/致畸性(E)

準備報告

需要加热才能完全溶解

重構

复溶后,等分并冷冻(-20°C)。 储备液在-20°C条件下可稳定保存3个月。

其他說明

Eggert, A., et al. 2001.Cancer Res.61, 1314.
Takebayashi, S., et al. 2001.Biochem.Biophys.Res. Commun.288, 921.
Zhu, W.G., et al. 2001.Cancer Res.61, 1327.
Hopkins-Donaldson, S., et al. 2000.Cancer Res.60, 4315.
Haaf, T. 1995.Pharmacol.Ther.65, 19.
Jones, P.A., and Taylor, S.M.1980.Cell20, 85.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

象形圖

Health hazardExclamation mark

訊號詞

Danger

危險分類

Acute Tox. 4 Oral - Eye Irrit. 2 - Muta. 2 - Repr. 1B - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類(WGK)

WGK 3


分析證明 (COA)

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