R1402

Raloxifene hydrochloride

solid

• 同義詞: Keoxifene hydrochloride, LY 156758, [6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]methanone hydrochloride
• 經驗公式（希爾表示法）: C₂₈H₂₇NO₄S · HCl
• CAS號碼: 82640-04-8
• 分子量：: 510.04
• MDL號碼: MFCD01938233
• 分類程式碼代碼: 51111800
• PubChem物質ID: 24278673
• NACRES: NA.77

屬性

• 形狀: solid
• 顏色: light yellow
• 溶解度: DMSO: soluble 28 mg/mL; H₂O: insoluble
• 起源: Eli Lilly
• SMILES 字串: Cl[H].Oc1ccc(cc1)-c2sc3cc(O)ccc3c2C(=O)c4ccc(OCCN5CCCCC5)cc4
• InChI: 1S/C28H27NO4S.ClH/c30-21-8-4-20(5-9-21)28-26(24-13-10-22(31)18-25(24)34-28)27(32)19-6-11-23(12-7-19)33-17-16-29-14-2-1-3-15-29;/h4-13,18,30-31H,1-3,14-17H2;1H
• InChI 密鑰: BKXVVCILCIUCLG-UHFFFAOYSA-N
• 基因資訊: human ... ESR2(2100)

描述

應用

Raloxifene hydrochloride has been used:

• as a competitive inhibitors for estrogen receptor α in breast cancer cells
• as an anti-resorptive agents to test its effect on improving bone mineral density (BMD) in six-month-old female ovariectomized rats
• to test effect on viability of esophageal adenocarcinoma cells

生化／生理作用

Raloxifene is a selective estrogen receptor modulator (SERM); acts as an anti-estrogen in both breast and uterine tissue while being estrogenic in bone. May have efficacy against estrogen-sensitive cancers.

Raloxifene is benzothiophene compound and is used in treating postmenopausal osteoporosis It comparatively induces lesser risk in developing thromboembolic events and cataracts compared to tamoxifen. Raloxifene also interacts with estrogen receptors and plasma proteins.

特點和優勢

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Eli Lilly. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

安全資訊

• 象形圖: GHS08
• 訊號詞: Warning
• 危險聲明: H351,H361d
• 防範說明: P201 - P202 - P280 - P308 + P313 - P405 - P501
• 危險分類: Carc. 2 - Repr. 2
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 2
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: Eyeshields, Gloves, type N95 (US)