推薦產品
product name
来曲唑, ≥98% (HPLC)
品質等級
化驗
≥98% (HPLC)
形狀
powder
顏色
white to off-white
溶解度
DMSO: >50 mg/mL
起源
Novartis
儲存溫度
2-8°C
SMILES 字串
N#CC(C=C1)=CC=C1C(N2C=NC=N2)C3=CC=C(C#N)C=C3
InChI
1S/C17H11N5/c18-9-13-1-5-15(6-2-13)17(22-12-20-11-21-22)16-7-3-14(10-19)4-8-16/h1-8,11-12,17H
InChI 密鑰
HPJKCIUCZWXJDR-UHFFFAOYSA-N
基因資訊
human ... CYP19A1(1588)
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應用
来曲唑已用于:
- 在类器官生长试验中测定其抑制力(48)
- 研究类固醇受体共激活因子1(SRC-1)介导的海马PSD-95内源性雌激素调节作用(49)
- 研究其对肿瘤诱导的痛觉过敏的作用 (50)
- 对大鼠进行激素干预(51)研究其对脂质运载蛋白-2(Lcn2)的作用(52)研究其对机械痛觉过敏和芳香化酶表达的作用(53)
生化/生理作用
来曲唑是一种佐剂,可用于治疗乳腺癌。
来曲唑是第三代非甾体芳香酶抑制剂。 它是芳香酶系统的竞争性抑制剂,因此可抑制雄激素向雌激素转化。来曲唑通过竞争性结合到该酶的细胞色素P450亚基的血红素上而抑制芳香酶,导致所有组织中雌激素的生物合成减少。
訊號詞
Warning
危險聲明
危險分類
Repr. 2 - STOT RE 2
儲存類別代碼
11 - Combustible Solids
水污染物質分類(WGK)
WGK 3
閃點(°F)
Not applicable
閃點(°C)
Not applicable
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號,寫有 ‘Lot’或‘Batch’.。
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