579000

Tamoxifen Citrate

Tamoxifen is a potent synthetic anti-estrogenic agent.

• 同義詞: Tamoxifen Citrate, Estrogen Receptor Signaling Regulator I
• 經驗公式（希爾表示法）: C₂₆H₂₉NO · xC₆H₈O₇
• CAS號碼: 54965-24-1
• 分子量：: 371.51 (salt-free basis)
• MDL號碼: MFCD00058321
• 分類程式碼代碼: 12352200

屬性

• 品質等級: 100
• 化驗: ≥99% (HPLC)
• 形狀: powder
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze
• 顏色: white to off-white
• 溶解度: ethanol: 5 mg/mL; methanol: 5 mg/mL; water: sparingly soluble
• 運輸包裝: ambient
• 儲存溫度: 2-8°C
• InChI: 1S/C26H29NO.C6H8O7/c1-4-25(21-11-7-5-8-12-21)26(22-13-9-6-10-14-22)23-15-17-24(18-16-23)28-20-19-27(2)3;7-3(8)1-6(13,5(11)12)2-4(9)10/h5-18H,4,19-20H2,1-3H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/b26-25-;
• InChI 密鑰: FQZYTYWMLGAPFJ-OQKDUQJOSA-N

描述

一般說明

A potent synthetic anti-estrogen. A cell-permeable and reversible inhibitor of protein kinase C (IC₅₀ = 10 µM). Induces apoptosis in human malignant glioma cell lines.

A potent synthetic anti-estrogenic agent. A cell-permeable and reversible inhibitor of protein kinase C (IC₅₀ = 10 µM). Induces apoptosis in human malignant glioma cell lines and inhibits prostate cancer cell growth by induction of p21 protein.

生化／生理作用

Cell permeable: yes

Primary Target
PKC

Product does not compete with ATP.

Reversible: yes

Target IC₅₀: 10 µM against protein kinase C

警告

Toxicity: Harmful & Carcinogenic / Teratogenic (E)

重構

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他說明

Rohlff, C., et al. 1998. Prostate 37, 51.
Couldwell, W.J., et al. 1994. FEBS Lett.345, 43.
Baltuch, G.H., et al. 1993. Neurosurgery33, 495.
Powis, G. 1991. Trends Pharmacol. Sci.12, 188.
Issandou, M., et al. 1990. Cancer Res.50, 5845.
O’Brian, C.A., et al. 1985. Cancer Res.45, 2462.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 象形圖: GHS07,GHS08,GHS09
• 訊號詞: Danger
• 危險聲明: H302 - H350 - H360D - H410
• 防範說明: P202 - P264 - P273 - P280 - P301 + P312 - P308 + P313
• 危險分類: Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1B - Repr. 1B
• 儲存類別代碼: 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable