P3053

青霉震颤素 A

≥95% (HPLC and TLC)

• 同義詞: Tremortin A
• 經驗公式（希爾表示法）: C₃₇H₄₄ClNO₆
• CAS號碼: 12627-35-9
• 分子量：: 634.20
• MDL號碼: MFCD00083465
• 分類程式碼代碼: 12352200
• PubChem物質ID: 24898385
• NACRES: NA.77

屬性

• 品質等級: 200
• 化驗: ≥95% (HPLC and TLC)
• 形狀: powder
• 儲存溫度: 2-8°C
• SMILES 字串: [H][C@]12CC[C@@]3(C)[C@@](O)(CC[C@@]4([H])[C@]5([H])OC(C)(C)[C@@]6([H])C[C@]7([H])C(=C)Cc8c(Cl)cc9[nH]c(c5c9c8[C@]67O)[C@]34C)[C@]1%10O[C@]%10([H])[C@@H](O)[C@H](O2)C(C)=C
• InChI: 1S/C37H44ClNO6/c1-15(2)28-27(40)31-37(45-31)23(43-28)9-10-33(6)34(7)18(8-11-35(33,37)41)29-25-24-21(39-30(25)34)14-20(38)17-12-16(3)19-13-22(32(4,5)44-29)36(19,42)26(17)24/h14,18-19,22-23,27-29,31,39-42H,1,3,8-13H2,2,4-7H3/t18-,19+,22+,23-,27-,28+,29-,31+,33+,34+,35-,36+,37-/m0/s1
• InChI 密鑰: JDUWHZOLEDOQSR-JKPSMKLGSA-N

描述

應用

Penitrem A has been used as Ca²⁺-Activated K⁺ (BK) channel blocker to study its effect on BK current in bag cell neurons.

生化／生理作用

Penitrem A intoxication causes ataxia, polypnea, and sustained tremors and may lead to seizures and death. Penitrem A affects the central and peripheral nervous system. It impairs the GABAergic neurotransmission in the cerebellum.

特點和優勢

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

其他說明

Originally isolated from Penicillium palitans

安全資訊

• 象形圖: GHS06
• 訊號詞: Danger
• 危險聲明: H300
• 防範說明: P301 + P330 + P331 + P310
• 危險分類: Acute Tox. 2 Oral
• 儲存類別代碼: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges