跳轉至內容
Merck
全部照片(2)

Key Documents

479306

Sigma-Aldrich

二氯化二胺(II)

≥99.9% trace metals basis

同義詞:

顺铂, 顺-二氯二氨基铂(II), 顺式-二胺二氯铂, 顺氯氨铂

登入查看組織和合約定價


About This Item

線性公式:
Pt(NH3)2Cl2
CAS號碼:
分子量::
300.05
EC號碼:
MDL號碼:
分類程式碼代碼:
12161600
PubChem物質ID:
NACRES:
NA.22

品質等級

化驗

≥99.9% trace metals basis

反應適用性

core: platinum
reagent type: catalyst

mp

270 °C (lit.)

抗生素活性譜

neoplastics

作用方式

DNA synthesis | interferes

SMILES 字串

N.N.Cl[Pt]Cl

InChI

1S/2ClH.2H3N.Pt/h2*1H;2*1H3;/q;;;;+2/p-2

InChI 密鑰

LXZZYRPGZAFOLE-UHFFFAOYSA-L

尋找類似的產品? 前往 產品比較指南

相關類別

應用

二氯化二胺(II)可用作模型药物以测试药物递送中各种药物载体的效率。
高活性化疗剂,可用于预防睾丸癌的进展。

生化/生理作用

强效的铂基抗肿瘤剂。与 DNA 二核苷酸 d(pGpG) 形成细胞毒性加合物,诱导链内交联。

象形圖

Skull and crossbonesHealth hazard

訊號詞

Danger

危險分類

Acute Tox. 2 Oral - Carc. 1B - Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges


從最近期的版本中選擇一個:

分析證明 (COA)

Lot/Batch Number

未看到正確版本?

如果您需要一個特定的版本,您可以透過批號來尋找特定憑證。

已經擁有該產品?

您可以在文件庫中找到最近購買的產品相關文件。

存取文件庫

Highly stable core-surface-crosslinked nanoparticles as cisplatin carriers for cancer chemotherapy.
Xu P, et al.
Colloids and Surfaces. B, Biointerfaces, 48(1), 50-57 (2006)
Synthesis of a new nanoparticle system based on electrostatic alginate?piperazine interactions.
Roman JV, et al.
Polymers For Advanced Technologies, 27(5), 623-629 (2016)
Pedro J Beltran et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 20(11), 2947-2958 (2014-04-15)
Insulin-like growth factor 1 receptor (IGF-IR) has been implicated in the pathogenesis of ovarian cancer. Ganitumab is an investigational, fully human monoclonal antibody against IGF-IR. Here, we explore the therapeutic potential of ganitumab for the treatment of ovarian cancer. The
Koji Tanaka et al.
Carcinogenesis, 36(8), 894-903 (2015-05-31)
There is increasing evidence that the expression of microRNA (miRNA) in cancer is associated with chemosensitivity but the mechanism of miRNA-induced chemoresistance has not been fully elucidated. The aim of this study was to examine the role of extracellular miRNA
Abdullah A Osman et al.
Cancer research, 75(7), 1205-1215 (2015-02-19)
TP53 is the most frequently altered gene in head and neck squamous cell carcinoma (HNSCC), with mutations occurring in over two thirds of cases; however, the predictive response of these mutations to cisplatin-based therapy remains elusive. In the current study

我們的科學家團隊在所有研究領域都有豐富的經驗,包括生命科學、材料科學、化學合成、色譜、分析等.

聯絡技術服務