推薦產品
形狀
lyophilized (white powder to sticky mass to hard pellet)
品質等級
比活性
≥9 units/μg protein (cyclic-AMP is not required for this activity)
分子量
40,862 Da
儲存溫度
−20°C
一般說明
蛋白激酶一种酶由两个亚单位（催化亚单位和调节亚单位）组成。催化亚基在环磷酸腺苷存在下作为单体存在，分子量为40,862 Da。
應用
牛心脏蛋白激酶A （PKA）催化亚单位已用于
- 研究PKA介导的IRK1（内向整流K+）通道抑制
- 体外 PKA磷酸化测定
- 体外亲和结合测定
- 研究PKA对功能活动运动神经元吸气驱动电流的影响
生化／生理作用
蛋白激酶A (PKA)控制Hedgehog信号转导，并参与增殖和命运决定。它可以使几种神经递质受体、转录因子和多种细胞内信号通路的成分磷酸化。
蛋白激酶A催化末端磷酸从ATP转移到存在于各种蛋白质上的苏氨酸或丝氨酸残基。这种蛋白质在没有环磷酸腺苷的情况下是无活性的，环磷酸腺苷是催化亚基和调节亚基结合在一起的地方。存在cAMP时，调节亚单位与cAMP结合并释放催化亚单位。
包裝
包装规格基于磷酸化单位
單位定義
在 pH 6.5、30°C，一单位每分钟可将 1.0 pmol磷酸盐从 ATP转化为水解和部分去磷酸化的酪蛋白，并可通过测量ADP产量进行测定。
外觀
冻干粉，含蔗糖和磷酸缓冲盐作为稳定剂。
準備報告
由蛋白激酶 A (P 5511) 制成
免責聲明
Please note that the pack size has been changed to align with the unit definition, while the number of phosphorylating units remain the same as before.
抑制劑
產品號碼
描述
訂價
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
客戶也查看了
Cyclic nucleotides in the nervous system
Basic Neurochemistry, 423-441 (2012)
F T Hartl et al.
The Journal of biological chemistry, 258(6), 3950-3955 (1983-03-25)
The physical and chemical properties of purified catalytic and regulatory subunits of type II cAMP-dependent protein kinase from bovine brain, skeletal muscle, and cardiac muscle were compared. The catalytic subunits from all three sources were identical with respect to molecular
Ken Tougane et al.
Plant physiology, 152(3), 1529-1543 (2010-01-26)
Abscisic acid (ABA) is postulated to be a ubiquitous hormone that plays a central role in seed development and responses to environmental stresses of vascular plants. However, in liverworts (Marchantiophyta), which represent the oldest extant lineage of land plants, the
Christopher M Bocchiaro et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 23(4), 1099-1103 (2003-02-25)
Plasticity underlying adaptive, long-term changes in breathing behavior is hypothesized to be attributable to the modulation of respiratory motoneurons by intracellular second-messenger cascades. In quiescent preparations, protein kinases, including cAMP-dependent protein kinase A (PKA), potentiate glutamatergic inputs. However, the dynamic
E Wischmeyer et al.
Proceedings of the National Academy of Sciences of the United States of America, 93(12), 5819-5823 (1996-06-11)
Strongly rectifying IRK-type inwardly rectifying K+ channels are involved in the control of neuronal excitability in the mammalian brain. Whole-cell patch-clamp experiments show that cloned rat IRK1 (Kir 2.1) channels, when heterologously expressed in mammalian COS-7 cells, are inhibited following
我們的科學家團隊在所有研究領域都有豐富的經驗，包括生命科學、材料科學、化學合成、色譜、分析等.
聯絡技術服務