跳轉至內容
Merck
全部照片(1)

重要文件

查看所有文件

C1172

Sigma-Aldrich

ML-9

≥99% (TLC), powder

同義詞:

1-(5-Chloronaphthalene-1-sulfonyl)-1H-hexahydro-1,4-diazepine hydrochloride

登入查看組織和合約定價
全部照片(1)

About This Item

線性公式:
C15H17N2O2SCl · HCl
CAS號碼:
105637-50-1
分子量：:
361.29
MDL號碼:
MFCD00065525
分類程式碼代碼:
12352202
PubChem物質ID:
24278297
NACRES:
NA.77

生物源

synthetic (organic)

化驗

≥99% (TLC)

形狀

powder

顏色

white

溶解度

ethanol: 10 mg/mL

儲存溫度

2-8°C

SMILES 字串

Cl.Clc1cccc2c(cccc12)S(=O)(=O)N3CCCNCC3

InChI

1S/C15H17ClN2O2S.ClH/c16-14-6-1-5-13-12(14)4-2-7-15(13)21(19,20)18-10-3-8-17-9-11-18;/h1-2,4-7,17H,3,8-11H2;1H

InChI 密鑰

ZNRYCIVTNLZOGI-UHFFFAOYSA-N

基因資訊

human ... SLC2A1(6513) , SLC2A4(6517)

應用

ML-9 has been used in the inhibition of myosin light chain kinase (MLCK) and non-muscle myosin IIA (NMIIA) in human corneal epithelial cells and HeLa cells.

生化／生理作用

ML-9 is myosin light chain kinase inhibitor. It inhibits insulin-induced translocation of glucose transporters GLUT4 and GLUT1 in a dose-dependent manner. ML-9 also inhibits agonist-induced Ca2+ entry into endothelial cells and catecholamine secretion in intact and permeabilized chromaffin cells. ML-9 promotes cell death in cancer cells by triggering accumulation of autophagic vacuoles. ML-9 impacts phosphorylation of myosin light chain kinase and alters trabecular meshwork shape and decreases intraocular pressure in rabbit eyes.

特點和優勢

This compound is featured on the Ca/CaMKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

分析證明 (COA)

輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。

已經擁有該產品？

您可以在文件庫中找到最近購買的產品相關文件。

存取文件庫

客戶也查看了

Slide 1 of 2

1 of 2

渥曼青霉素 from Penicillium funiculosum, ≥98% (HPLC and TLC)

Sigma-Aldrich

W1628

渥曼青霉素

红海海绵素A from sea sponge, ≥85% (HPLC), waxy solid

Sigma-Aldrich

L5163

红海海绵素A

The adrenal medulla (1992)
Letitia Weigand et al.
American journal of physiology. Lung cellular and molecular physiology, 290(2), L284-L290 (2005-09-13)
Endothelin-1 (ET-1), a potent vasoconstrictor, is believed to contribute to the pathogenesis of hypoxic pulmonary hypertension. Previously we demonstrated that contraction induced by ET-1 in intrapulmonary arteries (IPA) from chronically hypoxic (CH) rats occurred independently of changes in intracellular Ca2+
RhoD inhibits RhoC-ROCK-dependent cell contraction via PAK6
Durkin CH, et al.
Developmental Cell, 41(3), 315-329 (2017)
G Inoue et al.
The Journal of biological chemistry, 268(7), 5272-5278 (1993-03-05)
Treatment of 3T3-L1 adipocytes with insulin resulted in activation of 2-deoxyglucose transport activity and translocation of glucose transporters (GLUT4 and GLUT1) from the cytoplasmic space to the plasma membrane. ML-9 (a myosin light chain kinase inhibitor) inhibited insulin stimulation of
Amy Peng et al.
Neuron, 73(6), 1108-1115 (2012-03-27)
Synaptic vesicle exo- and endocytosis are usually driven by neuronal activity but can also occur spontaneously. The identity and differences between vesicles supporting evoked and spontaneous neurotransmission remain highly debated. Here we combined nanometer-resolution imaging with a transient motion analysis
查看所有相關論文

文章

Insulin Signaling and Energy Homeostasis

Glucose metabolism is regulated by the opposing actions of insulin and glucagon. Insulin is released from pancreatic ß cells in response to high blood glucose levels and regulates glucose metabolism through its actions on muscle, liver, and adipose tissue.

Aerobic Glycolysis and the Warburg Effect

We presents an article about the Warburg effect, and how it is the enhanced conversion of glucose to lactate observed in tumor cells, even in the presence of normal levels of oxygen. Otto Heinrich Warburg demonstrated in 1924 that cancer cells show an increased dependence on glycolysis to meet their energy needs, regardless of whether they were well-oxygenated or not.

我們的科學家團隊在所有研究領域都有豐富的經驗，包括生命科學、材料科學、化學合成、色譜、分析等.

聯絡技術服務