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Merck
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重要文件

L5163

Sigma-Aldrich

红海海绵素A

from sea sponge, ≥85% (HPLC), waxy solid

同義詞:

LAT-A, [1R-[1R*, 4Z, 8E, 10Z, 12S*, 15R*, 17R*(R*)]]-4-(17-羟基-5,12-二甲基-3-氧代-2,16-二氧杂双环[13.3.1]十九碳-4,8,10-三烯-17-基)-2-噻唑烷酮

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About This Item

經驗公式(希爾表示法):
C22H31NO5S
CAS號碼:
分子量::
421.55
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77

生物源

sea sponge

品質等級

化驗

≥85% (HPLC)

形狀

waxy solid

分子量

421.6

溶解度

DMSO: soluble
ethanol: soluble

儲存溫度

−20°C

SMILES 字串

C[C@H]1CC[C@@H]2C[C@H](C[C@@](O)(O2)[C@@H]3CSC(=O)N3)OC(=O)C=C(C)CC\C=C\C=C1

InChI

1S/C22H31NO5S/c1-15-7-5-3-4-6-8-16(2)11-20(24)27-18-12-17(10-9-15)28-22(26,13-18)19-14-29-21(25)23-19/h3-5,7,11,15,17-19,26H,6,8-10,12-14H2,1-2H3,(H,23,25)/b4-3+,7-5-,16-11-/t15-,17-,18-,19+,22-/m1/s1

InChI 密鑰

DDVBPZROPPMBLW-IZGXTMSKSA-N

一般說明

红海海绵素A是一种从红海海绵 Latrunculia magnifica中分离得到的毒素。它在 体外 参与纯肌动蛋白聚合的形态学改变。它通过与肌动蛋白的核苷酸裂缝结合而形成复合物,使肌动蛋白纤维伸长。

應用

红海海绵素A已被用作A549细胞的培养基补充剂,确定了A549人肺癌细胞中CAV9的内化机制。

生化/生理作用

红海海绵素A通过不同于细胞松弛素的机制抑制肌动蛋白聚合。红海海绵素A破坏了微丝介导的过程。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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E G Yarmola et al.
The Journal of biological chemistry, 275(36), 28120-28127 (2000-06-22)
Latrunculin A is used extensively as an agent to sequester monomeric actin in living cells. We hypothesize that additional activities of latrunculin A may be important for its biological activity. Our data are consistent with the formation of a 1:1
Peter J Wen et al.
Nature communications, 7, 12604-12604 (2016-09-01)
Vesicle fusion is executed via formation of an Ω-shaped structure (Ω-profile), followed by closure (kiss-and-run) or merging of the Ω-profile into the plasma membrane (full fusion). Although Ω-profile closure limits release but recycles vesicles economically, Ω-profile merging facilitates release but
Zhanghan Wu et al.
Nature communications, 9(1), 136-136 (2018-01-13)
Immune cells exhibit stimulation-dependent traveling waves in the cortex, much faster than typical cortical actin waves. These waves reflect rhythmic assembly of both actin machinery and peripheral membrane proteins such as F-BAR domain-containing proteins. Combining theory and experiments, we develop
Keiichiro Kushiro et al.
Scientific reports, 7(1), 4244-4244 (2017-06-28)
During metastasis, cancer cells are exposed to various three-dimensional microstructures within the body, but the relationship between cancer migration and three-dimensional geometry remain largely unclear. Here, such geometric effects on cancerous cells were investigated by characterizing the motility of various
Maureen Möckel et al.
Journal of virology, 93(16) (2019-05-31)
Dynamin GTPases, best known for their role in membrane fission of endocytic vesicles, provide a target for viruses to be exploited during endocytic uptake. Recently, we found that entry of herpes simplex virus 1 (HSV-1) into skin cells depends on

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