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Key Documents

C8273

Sigma-Aldrich

细胞松驰素D

from Zygosporium mansonii, ≥98% (TLC and HPLC), powder

同義詞:

细胞松弛素, 接柄孢菌素A

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About This Item

經驗公式(希爾表示法):
C30H37NO6
CAS號碼:
分子量::
507.62
Beilstein:
1632828
EC號碼:
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77

生物源

Zygosporium mansonii

品質等級

化驗

≥98% (TLC and HPLC)

形狀

powder

溶解度

DMSO: soluble
ethanol: soluble

抗生素活性譜

fungi

作用方式

DNA synthesis | interferes

儲存溫度

−20°C

SMILES 字串

[H][C@@]12[C@H](C)C(=C)[C@@H](O)[C@@H]3\C=C\C[C@H](C)C(=O)[C@](C)(O)\C=C\[C@@H](OC(C)=O)[C@@]13C(=O)N[C@H]2Cc4ccccc4

InChI

1S/C30H37NO6/c1-17-10-9-13-22-26(33)19(3)18(2)25-23(16-21-11-7-6-8-12-21)31-28(35)30(22,25)24(37-20(4)32)14-15-29(5,36)27(17)34/h6-9,11-15,17-18,22-26,33,36H,3,10,16H2,1-2,4-5H3,(H,31,35)/b13-9+,15-14+/t17-,18+,22-,23-,24+,25-,26+,29+,30+/m0/s1

InChI 密鑰

SDZRWUKZFQQKKV-JHADDHBZSA-N

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一般說明

细胞松弛素D是一种细胞渗透性真菌毒素。它破坏肌动蛋白微丝并激活p53依赖性通路,引起细胞周期在G1-S过渡期阻滞。细胞松弛素D抑制平滑肌收缩和胰岛素刺激的、非基础的葡萄糖转运。
细胞松弛素D(CytoD)常用于抑制肌动蛋白动力学,并用于研究其在细胞过程中的作用。通过结合G-肌动蛋白,这种来源于真菌的有机小分子化合物可作为G-肌动蛋白和丝切蛋白之间相互作用的抑制剂。此外,CytoD抑制丝切蛋白和F-肌动蛋白的结合,降低活细胞中肌动蛋白的聚合和解聚速率。

應用

细胞松弛素已用于:
  • 处理H9c2 细胞以研究细胞刚度和F-肌动蛋白细胞骨架的关系
  • 作为受体介导的内吞作用的抑制剂用于处理少突胶质前体细胞 (OPCs),以研究其抑制特异性细胞外囊泡(EV) 摄取途径的作用
  • 体外胚胎培养中用于人工激活卵母细胞

生化/生理作用

肌动蛋白聚合的强效抑制剂;可破坏肌动蛋白微丝;激活p53依赖性通路;抑制平滑肌收缩;抑制胰岛素刺激的葡萄糖转运。

象形圖

Skull and crossbones

訊號詞

Danger

危險聲明

危險分類

Acute Tox. 2 Oral

儲存類別代碼

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

水污染物質分類(WGK)

WGK 3

個人防護裝備

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges


分析證明 (COA)

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