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重要文件

C2618

Sigma-Aldrich

细胞松驰素D

Ready Made Solution, from Zygosporium mansonii, 5 mg/mL in DMSO

同義詞:

接柄孢菌素A

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About This Item

經驗公式(希爾表示法):
C30H37NO6
CAS號碼:
分子量::
507.62
Beilstein:
1632828
MDL號碼:
分類程式碼代碼:
51102829
PubChem物質ID:
NACRES:
NA.85

生物源

Zygosporium mansonii

品質等級

形狀

solution

濃度

5 mg/mL in DMSO

抗生素活性譜

fungi

作用方式

enzyme | interferes

運輸包裝

wet ice

儲存溫度

−20°C

SMILES 字串

[H][C@@]12[C@H](C)C(=C)[C@@H](O)[C@@H]3\C=C\C[C@H](C)C(=O)[C@](C)(O)\C=C\[C@@H](OC(C)=O)[C@@]13C(=O)N[C@H]2Cc4ccccc4

InChI

1S/C30H37NO6/c1-17-10-9-13-22-26(33)19(3)18(2)25-23(16-21-11-7-6-8-12-21)31-28(35)30(22,25)24(37-20(4)32)14-15-29(5,36)27(17)34/h6-9,11-15,17-18,22-26,33,36H,3,10,16H2,1-2,4-5H3,(H,31,35)/b13-9+,15-14+/t17-,18+,22-,23-,24+,25-,26+,29+,30+/m0/s1

InChI 密鑰

SDZRWUKZFQQKKV-JHADDHBZSA-N

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應用

细胞松弛素D是黑僵菌代谢物的同分异构体。细胞松弛素D具有抗菌和抗肿瘤活性。它还会有害于肌动蛋白丝的长时程增强作用(LTP)的维持。它与促进有利于肌动蛋白解聚的条件有关。

生化/生理作用

细胞渗透性真菌毒素;肌动蛋白聚合的有效抑制剂。破坏肌动蛋白微丝并激活p53依赖性通路,引起细胞周期在G1-S过渡期阻滞。抑制平滑肌收缩。抑制胰岛素刺激而非基础的葡萄糖转运。
肌动蛋白聚合的强效抑制剂;可破坏肌动蛋白微丝;激活p53依赖性通路;抑制平滑肌收缩;抑制胰岛素刺激的葡萄糖转运。

其他說明

保持容器密闭,并置于干燥通风处。打开后的容器必须小心重新密封并保持直立以防止泄漏。

儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

WGK 2

閃點(°F)

188.6 °F - closed cup - Solvent

閃點(°C)

87 °C - closed cup - Solvent

個人防護裝備

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)


分析證明 (COA)

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