475882-M

ML-9, Hydrochloride

A cell-permeable, reverisible and ATP-competitive inhibitor of myosin light chain kinase (K_i = 3.8 µM), protein kinase A (K_i = 32 µM), and protein kinase C (K_i = 54 µM).

• 同義詞: ML-9, Hydrochloride, 1-(5-Chloronaphthalene-1-sulfonyl)homopiperazine, HCl
• 經驗公式（希爾表示法）: C₁₅H₁₇ClN₂O₂S · xHCl
• CAS號碼: 105637-50-1
• 分子量：: 324.83 (free base basis)
• MDL號碼: MFCD00065525
• 分類程式碼代碼: 12352200

屬性

• 品質等級: 100
• 化驗: ≥98% (TLC)
• 形狀: solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; desiccated (hygroscopic); protect from light
• 顏色: white
• 溶解度: 50% ethanol: 10 mg/mL
• 儲存溫度: 2-8°C
• SMILES 字串: [S](=O)(=O)(N3CCNCCC3)c1c2c(c(ccc2)Cl)ccc1.[Cl-].[H+]
• InChI: 1S/C15H17ClN2O2S.ClH/c16-14-6-1-5-13-12(14)4-2-7-15(13)21(19,20)18-10-3-8-17-9-11-18;/h1-2,4-7,17H,3,8-11H2;1H
• InChI 密鑰: ZNRYCIVTNLZOGI-UHFFFAOYSA-N

描述

一般說明

A cell-permeable, reverisible and ATP-competitive inhibitor of myosin light chain kinase (K_i = 3.8 µM), protein kinase A (K_i = 32 µM), and protein kinase C (K_i = 54 µM). Also inhibits catecholamine secretion in intact and permeabilized chromaffin cells.

生化／生理作用

Primary Target
Mlck

Target K_i: 3.8 µM, 32 µM, 54 µM against myosin light chain kinase, protein kinase A, and protein kinase C, respectively

警告

Toxicity: Standard Handling (A)

準備報告

Further dilute with aqueous buffer just prior to use.

重構

Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C.

其他說明

Reig, J.A., et al. 1993. Neurochem. Res. 18, 317.
Nagatsu, T., et al. 1987. Biochem. Biophys. Res. Commun.143, 1045.
Saitoh, M., et al. 1987. J. Biol. Chem.262, 7796.
Saitoh, M., et al. 1986. Biochem. Biophys. Res. Commun.140, 280.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable