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Key Documents

M1809

Sigma-Aldrich

MRS 1523

>98% (HPLC)

同義詞:

3-Propyl-6-ethyl-5-[(ethylthio)carbonyl]-2 phenyl-4-propyl-3-pyridine carboxylate

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About This Item

經驗公式(希爾表示法):
C23H29NO3S
CAS號碼:
分子量::
399.55
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77

品質等級

化驗

>98% (HPLC)

形狀

oil

顏色

colorless to light brown

溶解度

DMSO: >10 mg/mL
H2O: insoluble

運輸包裝

wet ice

儲存溫度

2-8°C

SMILES 字串

CCCOC(=O)c1c(CCC)c(C(=O)SCC)c(CC)nc1-c2ccccc2

InChI

1S/C23H29NO3S/c1-5-12-17-19(23(26)28-8-4)18(7-3)24-21(16-13-10-9-11-14-16)20(17)22(25)27-15-6-2/h9-11,13-14H,5-8,12,15H2,1-4H3

InChI 密鑰

UUSHFEVEROROSP-UHFFFAOYSA-N

應用

MRS 1523 has been used as an inhibitor of adenosine receptors in SW1990 and BxPC3 pancreatic cancer cells, LX2 human hepatic stellate cells and human coronary smooth muscle cells.

生化/生理作用

MRS 1523 is a selective adenosine A3 receptor antagonist in the rat.

特點和優勢

This compound is featured on the Adenosine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

法律資訊

Sold under license from the National Institutes of Health

儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves


分析證明 (COA)

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C H Mitchell et al.
The American journal of physiology, 276(3 Pt 1), C659-C666 (1999-03-10)
Adenosine stimulates Cl- channels of the nonpigmented (NPE) cells of the ciliary epithelium. We sought to identify the specific adenosine receptors mediating this action. Cl- channel activity in immortalized human (HCE) NPE cells was determined by monitoring cell volume in
A H Li et al.
Journal of medicinal chemistry, 41(17), 3186-3201 (1998-08-14)
The structure-activity relationships of 6-phenyl-1,4-dihydropyridine derivatives as selective antagonists at human A3 adenosine receptors have been explored (Jiang et al. J. Med. Chem. 1997, 39, 4667-4675). In the present study, related pyridine derivatives have been synthesized and tested for affinity
The A3 adenosine receptor agonist, namodenoson, ameliorates non-alcoholic steatohepatitis in mice
Fishman P, et al.
International Journal of Molecular Medicine, 44(6), 2256-2264 (2019)
Shira Cohen et al.
Journal of immunology research, 2018, 2310970-2310970 (2018-06-05)
Interleukin-17 and interleukin-23 play major roles in the inflammatory process in psoriasis. The Gi protein-associated A3 adenosine receptor (A3AR) is known to be overexpressed in inflammatory cells and in peripheral blood mononuclear cells (PBMCs) of patients with autoimmune inflammatory conditions.
Nathaniel A Sowa et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 30(31), 10282-10293 (2010-08-06)
Prostatic acid phosphatase (PAP) is expressed in nociceptive dorsal root ganglion (DRG) neurons, functions as an ectonucleotidase, and generates adenosine extracellularly. Here, we found that PAP inhibits noxious thermal sensitivity and sensitization that is associated with chronic pain through sustained

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