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Merck
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重要文件

M8386

Sigma-Aldrich

α,β-亚甲基腺苷 5'-二磷酸 钠盐

CD73 inhibitor

同義詞:

AMP-CP

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About This Item

經驗公式(希爾表示法):
C11H17N5O9P2
CAS號碼:
分子量::
425.23
MDL號碼:
分類程式碼代碼:
41106305
PubChem物質ID:
NACRES:
NA.51

生物源

synthetic (organic)

化驗

≥98% (HPLC)

形狀

powder

溶解度

water: 50 mg/mL, clear to slightly hazy, colorless

儲存溫度

−20°C

SMILES 字串

[Na].Nc1ncnc2n(cnc12)C3OC(COP(O)(=O)CP(O)(O)=O)C(O)C3O

InChI

1S/C11H17N5O9P2.Na.H/c12-9-6-10(14-2-13-9)16(3-15-6)11-8(18)7(17)5(25-11)1-24-27(22,23)4-26(19,20)21;;/h2-3,5,7-8,11,17-18H,1,4H2,(H,22,23)(H2,12,13,14)(H2,19,20,21);;

InChI 密鑰

HEBWZOPLDYDXPJ-UHFFFAOYSA-N

相關類別

應用

αβ-亚甲基腺苷5′-二磷酸钠盐用作胞外核苷酸酶/CD73抑制剂,表征腺苷的产生模式 和作为 体外研究的抑制剂。

生化/生理作用

αβ-亚甲基腺苷5′-二磷酸(AMP-CP)是ADP类似物,具有抑制胞外核苷酸酶/CD73 的能力,通过CD73/胞外-5′-核苷酸酶,用于研究腺苷能信号调控。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Adenosine enhances progenitor cell recruitment and nerve growth via its A2B receptor during adult fin regeneration
Rampon C, et al.
Purinergic Signaling, 10(4), 595-602 (2014)
Ischemia-driven expression of CD73 confers tissue protection during liver ischemia/reperfusion.
Charles C Caldwell et al.
Gastroenterology, 135(5), 1460-1462 (2008-10-14)
Adenosine A3 receptor elicits chemoresistance mediated by multiple resistance-associated protein-1 in human glioblastoma stem-like cells.
Torres A
Oncotarget, 7, 67373-67386 (2016)
Charles Dumontet et al.
European journal of medicinal chemistry, 157, 1051-1055 (2018-09-04)
The ecto-5'-nucleotidase CD73 has emerged as an important drug target in oncoimmunology as well as in other diseases. We describe new ADP analogues as CD73 inhibitors based on the replacement of the adenosine moiety, in the reference inhibitor APCP, by
Camilla Mohlin et al.
Pharmacology, 84(4), 196-202 (2009-09-05)
Extracellular ATP may be metabolized to AMP and adenosine by the ectonucleotidases CD39 and CD73 and, in this study, we characterized the pathways for adenosine formation in human urinary tract epithelial cells. Bladder (RT4) and kidney (A498) epithelial cells were

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