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EPS002

Sigma-Aldrich

MS-275

A HDAC1 and HDAC3 inhibitor

同義詞:

MS-275 (Entinostat, SNDX-275), 3-吡啶基甲基[[4-[[(2-氨基苯基)氨基]羰基]苯基]甲基]氨基甲酸酯, N-(2-氨基苯基)-4-[N-(吡啶-3-甲氧基羰基)氨甲基]苯甲酰胺

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About This Item

經驗公式(希爾表示法):
C21H20N4O3
CAS號碼:
分子量::
376.41
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.41

化驗

≥99%

溶解度

DMSO: 38 mg/mL

儲存溫度

−20°C

SMILES 字串

Nc1ccccc1NC(=O)c2ccc(CNC(=O)OCc3cccnc3)cc2

InChI

1S/C21H20N4O3/c22-18-5-1-2-6-19(18)25-20(26)17-9-7-15(8-10-17)13-24-21(27)28-14-16-4-3-11-23-12-16/h1-12H,13-14,22H2,(H,24,27)(H,25,26)

InChI 密鑰

INVTYAOGFAGBOE-UHFFFAOYSA-N

尋找類似的產品? 前往 產品比較指南

一般說明

优先于HDAC3(IC50=8 μM)抑制HDAC1(IC50 = 300nM)。 对HDAC8(IC50>100 μM)无抑制活性。

應用

MS-275已被用作组蛋白脱乙酰酶-1抑制剂。

生化/生理作用

HDAC抑制剂,抗增殖。

象形圖

Skull and crossbonesHealth hazard

訊號詞

Danger

危險聲明

危險分類

Acute Tox. 3 Oral - Repr. 1A

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

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