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D1542

Sigma-Aldrich

1,4-二脱氧-1,4-亚氨基-D-阿拉伯糖醇 盐酸盐

enzyme inhibitor

同義詞:

2-羟甲基-3,4-吡咯烷二醇 盐酸盐

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About This Item

經驗公式（希爾表示法）:
C5H11NO3 · HCl
CAS號碼:
100991-92-2
分子量：:
169.61
MDL號碼:
MFCD03427380
分類程式碼代碼:
12352202
PubChem物質ID:
24278359
NACRES:
NA.77

品質等級

200

化驗

≥98% (TLC)

形狀

solid

儲存條件

under inert gas

溶解度

water: 19.60-20.40 mg/mL, clear, colorless to faintly yellow

儲存溫度

2-8°C

SMILES 字串

Cl.OC[C@H]1NC[C@@H](O)[C@@H]1O

InChI

1S/C5H11NO3.ClH/c7-2-3-5(9)4(8)1-6-3;/h3-9H,1-2H2;1H/t3-,4-,5-;/m1./s1

InChI 密鑰

PZGVJCJRMKIVLJ-DEVUXVJFSA-N

基因資訊

human ... PYGB(5834) , PYGBL(5835) , PYGL(5836) , PYGM(5837)
mouse ... Gaa(14387) , Glb1(12091) , Treh(58866)
rat ... Man2a1(25478) , Pygl(64035) , Si(25588)

一般說明

1,4-二脱氧-1,4-亚氨基-D-阿拉伯糖醇是一种天然存在的吡咯烷生物碱。它存在于Arachniodes standishii 和 Angylocalyx boutiqueanus中。

應用

1,4-二脱氧-1,4-亚氨基-D-阿拉伯糖醇盐酸盐已用作α-葡萄糖苷酶（GAA）抑制剂。

生化／生理作用

糖原磷酸化酶和α-葡萄糖苷酶的抑制剂。

注意

极易吸湿，在氩中储存和处理

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

分析證明 (COA)

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A new resorufin-based $\alpha$-glucosidase assay for high-throughput screening
Motabar O, et al.
Analytical Biochemistry, 390(1), 79-84 (2009)
Tetrahedron Letters, 42, 5685-5685 (1986)
The synthesis from d-xylose of the potent and specific enantiomeric glucosidase inhibitors, 1, 4-dideoxy-1, 4-imino-d-arabinitol and 1, 4-dideoxy-1, 4-imin
Fleet GWJ and Smith PW
Tetrahedron, 42(20), 5685-5692 (1986)
Omid Motabar et al.
Analytical biochemistry, 390(1), 79-84 (2009-04-18)
Mutations in alpha-glucosidase cause accumulation of glycogen in lysosomes, resulting in Pompe disease, a lysosomal storage disorder. Small molecule chaperones that bind to enzyme proteins and correct the misfolding and mistrafficking of mutant proteins have emerged as a new therapeutic
Junnan Xu et al.
Frontiers in pharmacology, 9, 873-873 (2018-08-23)
Understanding the mechanistic basis for temozolomide (TMZ)-induced glioma resistance is an important obstacle in developing an effective form of chemotherapy for this type of tumor. Glycogenolysis is known to play an essential role in cellular proliferation and potassium homeostasis and
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