PYGL
phosphorylase, glycogen, liver
別名:
GSD6
Species:
Human PYGL (5836), Mouse Pygl (110095), Rat Pygl (64035), domestic guinea pig Pygl (100721433), naked mole-rat Pygl (101723998), cow PYGL (505472), sheep PYGL (554320), Zebrafish pygl (493916), chicken PYGL (378909), domestic cat PYGL (101089364) ...詳細
UniProtKB ID:
遺伝子ID:
- Human(5836) Summary: This gene encodes a homodimeric protein that catalyses the cleavage of alpha-1,4-glucosidic bonds to release glucose-1-phosphate from liver glycogen stores. This protein switches from inactive phosphorylase B to active phosphorylase A by phosphorylation of serine residue 15. Activity of this enzyme is further regulated by multiple allosteric effectors and hormonal controls. Humans have three glycogen phosphorylase genes that encode distinct isozymes that are primarily expressed in liver, brain and muscle, respectively. The liver isozyme serves the glycemic demands of the body in general while the brain and muscle isozymes supply just those tissues. In glycogen storage disease type VI, also known as Hers disease, mutations in liver glycogen phosphorylase inhibit the conversion of glycogen to glucose and results in moderate hypoglycemia, mild ketosis, growth retardation and hepatomegaly. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Feb 2011]
- Mouse(110095) liver glycogen phosphorylase
- Rat(64035) phosphorylase, glycogen, liver
- domestic guinea pig(100721433) phosphorylase, glycogen, liver
- naked mole-rat(101723998) phosphorylase, glycogen, liver
- cow(505472) phosphorylase, glycogen, liver
- sheep(554320) phosphorylase, glycogen, liver
- Zebrafish(493916) phosphorylase, glycogen; liver (Hers disease, glycogen storage disease type VI)
- chicken(378909) phosphorylase, glycogen, liver
- domestic cat(101089364) phosphorylase, glycogen, liver
- Horse(100066726) phosphorylase, glycogen, liver
- dog(403738) phosphorylase, glycogen, liver
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Antibodies
製品番号
詳細
交差性
アプリケーション
抗PYGL ウサギ宿主抗体, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
交差性
human
アプリケーション
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
抗PYGL ウサギ宿主抗体, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
交差性
human
アプリケーション
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
抗PYGL抗体 ウサギ宿主抗体, purified immunoglobulin, buffered aqueous solution,
交差性
human
アプリケーション
western blot
Small Molecule - Inhibitor
製品番号
詳細
Species
esiRNA
製品番号
詳細
Species