推薦產品
生物源
synthetic (organic)
品質等級
化驗
≥99% (TLC)
形狀
solid
儲存溫度
−20°C
SMILES 字串
CCCNC(=O)[C@H]1O[C@@H]1C(=O)N[C@@H](C(C)CC)C(=O)N2CCC[C@H]2C(=O)OC
InChI
1S/C19H31N3O6/c1-5-9-20-16(23)14-15(28-14)17(24)21-13(11(3)6-2)18(25)22-10-7-8-12(22)19(26)27-4/h11-15H,5-10H2,1-4H3,(H,20,23)(H,21,24)/t11?,12-,13-,14-,15-/m0/s1
InChI 密鑰
XGWSRLSPWIEMLQ-RQLZCWDZSA-N
應用
使用CA-074甲酯用作心肌细胞、HeLa细胞和胰腺癌PANC-1细胞中的组织蛋白酶B抑制剂。
生化/生理作用
CA-074甲酯是CA-074的细胞渗透性类似物。它是组织蛋白酶B尤其胞内型的抑制剂,可通过酯酶作用在细胞内转化为活性CA-074。CA-074甲酯还可抑制组织蛋白酶L。
特點和優勢
这种化合物是凋亡研究的特色产品。点击此处发现更多特色凋亡产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
儲存類別代碼
11 - Combustible Solids
水污染物質分類(WGK)
WGK 3
閃點(°F)
Not applicable
閃點(°C)
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號,寫有 ‘Lot’或‘Batch’.。
客戶也查看了
The cathepsin B-selective inhibitors CA-074 and CA-074Me inactivate cathepsin L under reducing conditions
Open enzyme inhibition Journal, 4(1), 3493-3500 (2011)
An intracellular form of cathepsin B contributes to invasiveness in cancer
Cancer Research, 61(8), 3493-3500 (2001)
Cells, 9(5) (2020-05-30)
Studies have shown that the process of extracellular vesicles (EVs) secretion and lysosome status are linked. When the lysosome is under stress, the cells would secrete more EVs to maintain cellular homeostasis. However, the process that governs lysosomal activity and
Preliminary research on the pathological role of cathepsin-B in subcutaneous heteroplastic pancreatic carcinoma in nude mice
Chinese Medical Journal (English Edition), 122(20), 2489-2496 (2009)
Archives of biochemistry and biophysics, 299(2), 377-380 (1992-12-01)
The specificity of compound CA074 [N-(L-3-trans-propylcarbamoyloxirane-2-carbonyl)-L-isoleucyl-L-pro line] for the inactivation of cathepsin B was quantified in in vitro measurements with cysteine endopeptidases from cattle, it being found that the compound is a very rapid inactivator of cathepsin B (rate constant
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