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Merck
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Key Documents

C5732

Sigma-Aldrich

CA-074

≥98% (HPLC)

同義詞:

(L-3-反式-(丙基氨基甲酰基)环氧乙烷-2-羰基)-L-异亮烷基-L-脯氨酸

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About This Item

經驗公式(希爾表示法):
C18H29N3O6
CAS號碼:
分子量::
383.44
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77

生物源

synthetic (organic)

品質等級

化驗

≥98% (HPLC)

形狀

powder

溶解度

methanol: 1 mg/mL, clear, colorless

儲存溫度

−20°C

SMILES 字串

CCCNC(=O)[C@H]1O[C@@H]1C(=O)N[C@@H]([C@H](C)CC)C(=O)N2CCC[C@H]2C(O)=O

InChI

1S/C18H29N3O6/c1-4-8-19-15(22)13-14(27-13)16(23)20-12(10(3)5-2)17(24)21-9-6-7-11(21)18(25)26/h10-14H,4-9H2,1-3H3,(H,19,22)(H,20,23)(H,25,26)/t10?,11-,12-,13-,14-/m0/s1

InChI 密鑰

ZEZGJKSEBRELAS-NSIINPIOSA-N

應用

CA-074 已被用作组织蛋白酶 B 抑制剂:
  • 利用 HeLa 细胞研究其对携带 R642M 和 N714K 的 S 蛋白的假型病毒的影响
  • 确定自噬在葡萄糖缺乏(GD)诱导的损伤中的作用
  • 研究其暴露于组织蛋白酶 B(CATB)对神经元功能的影响

生化/生理作用

CA-074 是组织蛋白酶 B 的有效和选择性抑制剂。它有助于研究组织蛋白酶 B 在体内的生物学功能。研究表明,CA-074 在还原条件下也能抑制组织蛋白酶 L。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


分析證明 (COA)

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M Murata et al.
FEBS letters, 280(2), 307-310 (1991-03-25)
A series of new epoxysuccinyl peptides were designed and synthesized to develop a specific inhibitor of cathepsin B. Of these compounds, N-(L-3-trans-ethoxycarbonyloxirane-2-carbonyl)-L-isoleucyl-L-proli ne (compound CA-030) and N-(L-3-trans-propylcarbamoyloxirane-2-carbonyl)-L-isoleucyl-L-prol ine (compound CA-074) were the most potent and specific inhibitors of cathepsin B
Igor Stern et al.
The Biochemical journal, 381(Pt 2), 511-517 (2004-04-16)
The crystal structure of the inhibitor NS-134 in complex with bovine cathepsin B reveals that functional groups attached to both sides of the epoxysuccinyl reactive group bind to the part of active-site cleft as predicted. The -Leu-Pro-OH side binds to
Clément Naudin et al.
PloS one, 6(9), e25577-e25577 (2011-10-08)
Cysteine cathepsins have emerged as new players in inflammatory lung disorders. Their activities are dramatically increased in the sputum of cystic fibrosis (CF) patients, suggesting that they are involved in the pathophysiology of CF. We have characterized the cathepsins in
Eduardo Villalobo et al.
Eukaryotic cell, 2(6), 1234-1245 (2003-12-11)
The process of excystment of Sterkiella histriomuscorum (Ciliophora, Oxytrichidae) leads in a few hours, through a massive influx of water and the resorption of the cyst wall, from an undifferentiated resting cyst to a highly differentiated and dividing vegetative cell.
Arjen R de Boer et al.
Analytical chemistry, 77(24), 7894-7900 (2005-12-15)
The potential of high-temperature liquid chromatography (HTLC) was investigated in an on-line combination with a screening system for bioactive compounds against the enzyme cathepsin B. Samples were separated by HTLC and subsequently analyzed by an on-line continuous-flow enzymatic assay. Detection

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