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重要文件

S8260

Sigma-Aldrich

沙丁胺醇

≥96% (GC), powder, β2 adrenoceptor agonist

同義詞:

α-[(-丁基氨基)甲基]-4-羟基--二甲苯-α,α′-二醇, Albuterol

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About This Item

經驗公式(希爾表示法):
C13H21NO3
CAS號碼:
分子量::
239.31
Beilstein:
6405698
EC號碼:
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77

產品名稱

沙丁胺醇,

品質等級

溶解度

methanol: complete 50 mg/ml, clear, colorless to yellow

起源

GlaxoSmithKline

SMILES 字串

CC(C)(C)NCC(O)c1ccc(O)c(CO)c1

InChI

1S/C13H21NO3/c1-13(2,3)14-7-12(17)9-4-5-11(16)10(6-9)8-15/h4-6,12,14-17H,7-8H2,1-3H3

InChI 密鑰

NDAUXUAQIAJITI-UHFFFAOYSA-N

基因資訊

human ... ADRB2(154)

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應用

Salbutamol was administered to primate model to study the bronchoconstriction in chronic allergic asthma.20 Salbutamol was used as a standard for rapid pharmacokinetic screening of human plasma samples using HPLC.21

生化/生理作用

Salbutamol is a β2 adrenoceptor agonist with short acting bronchodilation and anti-inflammatory effects. It relaxes the airway smooth muscles and inhibits bronchoconstriction induced by adenosine-5′ -monophosphate (AMP).1 Salbutamol is particularly effective in treatment of asthma as it provides immediate relief.2
β2-肾上腺素受体激动剂

特點和優勢

This compound is featured on the β-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

象形圖

Exclamation mark

訊號詞

Warning

危險分類

Acute Tox. 4 Oral - Aquatic Chronic 3 - Eye Irrit. 2 - Skin Sens. 1B

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 2

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


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分析證明 (COA)

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Huib A M Kerstjens et al.
The Lancet. Respiratory medicine, 3(5), 367-376 (2015-02-16)
In patients with severe asthma, tiotropium improves lung function and exacerbation risk when added to high-dose inhaled corticosteroids plus long-acting β2 agonists. We aimed to assess the safety and efficacy of tiotropium in patients with moderate asthma who were symptomatic
James Fingleton et al.
The Journal of allergy and clinical immunology, 136(3), 601-609 (2015-03-10)
Asthma and chronic obstructive pulmonary disease (COPD) are heterogeneous disorders encompassing different phenotypes of airflow obstruction, which might differ in their response to treatment. The aim of this study was to determine distinct phenotypes comprising the syndromes of asthma and
M Reza Maleki-Yazdi et al.
Respiratory medicine, 108(12), 1752-1760 (2014-12-03)
Combinations of inhaled long-acting bronchodilator therapies such as muscarinic antagonists and β2-agonists may be more effective than monotherapy in the treatment of chronic obstructive pulmonary disease (COPD). This study was a 24-week, Phase III, multicenter, randomized, blinded, double-dummy, parallel-group study
L Gnatiuc et al.
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, 19(1), 21-30 (2014-12-19)
Increasing access to essential respiratory medicines and influenza vaccination has been a priority for over three decades. Their use remains low in low- and middle-income countries (LMICs), where little is known about factors influencing use, or about the use of
Anna Zaia Carolina Rodrigues et al.
Molecular and cellular neurosciences, 95, 59-70 (2019-02-15)
Increasing evidence indicates that, first, the sympathetic nervous system interacts extensively with both vasculature and skeletal muscle fibers near neuromuscular junctions (NMJs) and, second, its neurotransmitter, noradrenaline, influences myofiber molecular composition and function and motor innervation. Since sympathomimetic agents have

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