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About This Item
經驗公式（希爾表示法）:
C22H26N2O4
CAS號碼:
分子量：:
382.45
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77
推薦產品
化驗
≥90% (TLC)
成份
Peptide Content, >90%
溶解度
DMSO: 26 mg/mL
H2O: insoluble
methanol: soluble
運輸包裝
wet ice
儲存溫度
2-8°C
SMILES 字串
[H]C(=O)C(Cc1ccccc1)NC(=O)[C@@H](NC(=O)OCc2ccccc2)C(C)C
InChI
1S/C22H26N2O4/c1-16(2)20(24-22(27)28-15-18-11-7-4-8-12-18)21(26)23-19(14-25)13-17-9-5-3-6-10-17/h3-12,14,16,19-20H,13,15H2,1-2H3,(H,23,26)(H,24,27)/t19?,20-/m0/s1
InChI 密鑰
NGBKFLTYGSREKK-ANYOKISRSA-N
基因資訊
human ... CAPN1(823) , CAPN2(824)
Amino Acid Sequence
Z-Val-Phe-al
應用
MDL 28170已被用作钙蛋白酶抑制剂：
- 在大鼠心脏骤停模型中研究对神经炎症和坏死的影响
- 分析对牛肉半膜肌神经元一氧化氮合酶(nNOS)降解的影响
- 研究对大鼠脑损伤的保护作用及骨髓间充质干细胞在大鼠脑内的存活率
生化／生理作用
MDL 28170 是一种有效的细胞渗透性钙蛋白酶 I 和 II 抑制剂；减少培养的背根神经节神经元中辣椒素介导的细胞死亡。减少 H2O2 和 A23187 处理的 PC12 细胞凋亡的发生。γ-分泌酶抑制剂。
MDL 28170对大鼠脊髓损伤、局灶性脑缺血和新生儿缺氧缺血均有神经保护作用。它还有抗炎和抗神经退化特性。MDL 28170可穿过血脑屏障，并轻松穿透细胞膜。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
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