A7410

Amiloride hydrochloride hydrate

≥98% (HPLC), powder, T-type calcium channel blocker

• 同義詞: N-Amidino-3,5-diamino-6-chloropyrazinecarboxamide hydrochloride hydrate
• 經驗公式（希爾表示法）: C₆H₈ClN₇O · HCl · xH₂O
• CAS號碼: 2016-88-8
• 分子量：: 266.09 (anhydrous basis)
• MDL號碼: MFCD03703482
• 分類程式碼代碼: 12352200
• PubChem物質ID: 24277817
• NACRES: NA.77

屬性

• product name: Amiloride hydrochloride hydrate, ≥98% (HPLC), powder
• 化驗: ≥98% (HPLC)
• 形狀: powder
• 顏色: yellow
• mp: 285-288 °C (dec.)
• 溶解度: H₂O: 50 mg/mL, clear, yellow-green
• 起源: Perrigo
• 儲存溫度: room temp
• SMILES 字串: O.Cl.NC(=N)NC(=O)c1nc(Cl)c(N)nc1N
• InChI: 1S/C6H8ClN7O.ClH.H2O/c7-2-4(9)13-3(8)1(12-2)5(15)14-6(10)11;;/h(H4,8,9,13)(H4,10,11,14,15);1H;1H2
• InChI 密鑰: WDZJJRLYFQNCQL-UHFFFAOYSA-N
• 基因資訊: human ... ABP1(26) , ACCN1(40) , ACCN2(41) , PLAU(5328) , SCNN1A(6337) , SCNN1B(6338) , SCNN1D(6339) , SCNN1G(6340) , SLC9A1(6548) , TNF(7124) ; mouse ... Abp1(76507) , Accn1(11418) , Accn2(11419) , Plau(18792) , Scnn1a(20276) , Scnn1b(20277) , Scnn1d(140501) , Scnn1g(20278) , Slc9a1(20544) ; rat ... Abp1(65029) , Accn1(25364) , Accn2(79123) , Plau(25619) , Scnn1a(25122) , Scnn1b(24767) , Scnn1g(24768) , Slc9a1(24782)

描述

應用

Amiloride is a selective T-type calcium channel blocker, an epithelial sodium channel blocker and a selective inhibitor of urokinase plasminogen activator (uPA). Amiloride has been used in a study to develop an alternative treatment for constipation.

生化／生理作用

Selective T-type calcium channel blocker and blocker of epithelial sodium channel. Selective inhibitor of urokinase plasminogen activator (uPA).

特點和優勢

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Acid-Sensing (Proton-gated) Ion Channels (ASICs) and Imidazoline Binding Sites pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Perrigo. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

注意

Protect from light.

安全資訊

• 象形圖: GHS06
• 訊號詞: Danger
• 危險聲明: H301
• 防範說明: P264 - P270 - P301 + P310 - P405 - P501
• 危險分類: Acute Tox. 3 Oral
• 儲存類別代碼: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges