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重要文件

SML1360

Sigma-Aldrich

卡立泊来德

≥98% (HPLC)

同義詞:

HOE-642, N-(二氨基亚甲基)-4-异丙基-3-(甲磺酰基)苯甲酰胺, N-(氨基亚氨基甲基)-4-(1-甲基乙基)-3-(甲磺酰基)-苯甲酰胺

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About This Item

經驗公式(希爾表示法):
C12H17N3O3S
CAS號碼:
分子量::
283.35
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77

品質等級

化驗

≥98% (HPLC)

形狀

powder

顏色

white to beige

溶解度

DMSO: 20 mg/mL, clear

儲存溫度

2-8°C

SMILES 字串

NC(NC(C1=CC(S(C)(=O)=O)=C(C(C)C)C=C1)=O)=N

InChI

1S/C12H17N3O3S/c1-7(2)9-5-4-8(11(16)15-12(13)14)6-10(9)19(3,17)18/h4-7H,1-3H3,(H4,13,14,15,16)

InChI 密鑰

IWXNYAIICFKCTM-UHFFFAOYSA-N

生化/生理作用

卡立泊来德是 Na +/H + 交换子亚型 1 (NHE-1) 的选择性抑制剂。
卡立泊来德是 Na +/H + 交换子亚型 1 (NHE-1) 的选择性抑制剂,也称为 Na +/H + 逆向转运蛋白。卡立泊来德已显示出心脏保护和抗心律失常作用,最近对其抗癌活性进行了研究。
卡立泊来德是一种钠氢交换抑制剂 ,可减少缺血/再灌注时肌红蛋白的释放,减少缺血时 NE(去甲肾上腺素)的释放。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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分析證明 (COA)

Lot/Batch Number

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Zhuoqun Fang et al.
Shock (Augusta, Ga.), 54(6), 819-827 (2020-06-05)
Na/H exchanger 1 (NHE1) is a ubiquitously expressed protein on mammalian plasma membranes and involved in cell apoptosis and tissue injury. Our previous study found that NHE1 inhibition prevents burn-induced acute lung injury (ALI). However, the potential mechanism of NHE1
Jair C Kwan et al.
Heart, lung & circulation, 24(3), 306-318 (2014-12-03)
Storage of donor hearts in cardioplegic solutions supplemented with agents that mimic the ischaemic preconditioning response enhanced their post-reperfusion function. The present study examines the minimisation of cell death and activation of pro-survival signalling directed towards maintenance of mitochondrial homeostasis
Shigeru Sakurai et al.
Life sciences, 114(2), 102-106 (2014-08-21)
To examine the effects of cariporide, a Na(+)/H(+) exchanger-1 inhibitor, on cardiac norepinephrine (NE) and myoglobin release during myocardial ischemia/reperfusion by applying a microdialysis technique to the rabbit heart. In anesthetized rabbits, two dialysis probes were implanted into the left

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