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Merck
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重要文件

A1086

Sigma-Aldrich

N-乙酰基-Asp-Glu-Val-Asp-7-酰胺基-4-甲基香豆素

≥97% (HPLC), powder

同義詞:

Ac-DEVD-AMC

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About This Item

經驗公式(希爾表示法):
C30H37N5O13
CAS號碼:
分子量::
675.64
MDL號碼:
分類程式碼代碼:
12352209
PubChem物質ID:
NACRES:
NA.77

品質等級

化驗

≥97% (HPLC)

形狀

powder

成份

Peptide content, ~65%

顏色

white

溶解度

DMSO: 10 mM

儲存溫度

−20°C

SMILES 字串

CC(C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(C)=O)C(=O)N[C@@H](CC(O)=O)C(=O)Nc1ccc2C(C)=CC(=O)Oc2c1

InChI

1S/C30H37N5O13/c1-13(2)26(35-27(44)18(7-8-22(37)38)33-29(46)19(11-23(39)40)31-15(4)36)30(47)34-20(12-24(41)42)28(45)32-16-5-6-17-14(3)9-25(43)48-21(17)10-16/h5-6,9-10,13,18-20,26H,7-8,11-12H2,1-4H3,(H,31,36)(H,32,45)(H,33,46)(H,34,47)(H,35,44)(H,37,38)(H,39,40)(H,41,42)/t18-,19-,20-,26-/m0/s1

InChI 密鑰

ALZSTTDFHZHSCA-RNVDEAKXSA-N

應用

N-乙酰基-Asp-Glu-Val-Asp-7-酰胺基-4-甲基香豆素已被用作人结肠癌细胞系和骨髓间充质干细胞中caspase-3检测的底物。

生化/生理作用

caspase 3的荧光底物,而caspase 3是一种当细胞暴露于凋亡条件下时会被快速激活并裂解聚(ADP-核糖)聚合酶的蛋白酶。

特點和優勢

该化合物在受体分类和信号转导手册的 半胱天冬酶 页面上有详细描述。如需浏览其他手册页面,请点击此处
这种化合物是细胞凋亡研究的特色产品。点击此处发现更多特色细胞凋亡产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。

相關產品

產品號碼
描述
訂價

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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