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Key Documents

A0835

Sigma-Aldrich

N-Acetyl-Asp-Glu-Val-Asp-al

≥95%, powder

同義詞:

Ac-DEVD-CHO

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About This Item

經驗公式(希爾表示法):
C20H30N4O11
CAS號碼:
分子量::
502.47
MDL號碼:
分類程式碼代碼:
12352209
PubChem物質ID:
NACRES:
NA.32

生物源

synthetic

品質等級

化驗

≥95%

形狀

powder

顏色

white

溶解度

H2O: 1 mg/mL

儲存溫度

−20°C

SMILES 字串

[H]C(=O)C(CC(O)=O)NC(=O)C(NC(=O)C(CCC(O)=O)NC(=O)C(CC(O)=O)NC(C)=O)C(C)C

InChI

1S/C20H30N4O11/c1-9(2)17(20(35)22-11(8-25)6-15(29)30)24-18(33)12(4-5-14(27)28)23-19(34)13(7-16(31)32)21-10(3)26/h8-9,11-13,17H,4-7H2,1-3H3,(H,21,26)(H,22,35)(H,23,34)(H,24,33)(H,27,28)(H,29,30)(H,31,32)

InChI 密鑰

UMBVAPCONCILTL-UHFFFAOYSA-N

Amino Acid Sequence

NAc-Asp-Glu-Val-Asp-al

一般說明

N-Acetyl-Asp-Glu-Val-Asp-al (Ac-DEVD-CHO) 是一种具有N端乙酰化和C端醛共轭的四肽。

應用

N-Acetyl-Asp-Glu-Val-Asp-al已在肌肉样品、平滑肌细胞和Jurkat T细胞中被用作半胱氨酸蛋白酶抑制剂。

生化/生理作用

N-Acetyl-Asp-Glu-Val-Asp-al (Ac-DEVD-CHO) 可通过其半胱氨酸蛋白酶抑制剂的功能性有助于顿抑心肌的恢复。
IL-1β的可逆性抑制剂;转化酶(ICE);通过凋亡蛋白(caspase 3)抑制聚(ADP-核糖)聚合酶的切割。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


分析證明 (COA)

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